Phylogeny of the Simbu serogroup of the genus Bunyavirus

M. F. Saeed, L. Li, H. Wang, Scott Weaver, Alan Barrett

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The Simbu serogroup of the genus Bunyavirus, family Bunyaviridae contains 25 viruses. Previous serological studies provided important information regarding some but not all of the relationships among Simbu serogroup viruses. This report describes the nucleotide sequence determination of the nucleocapsid (N) gene of the small genomic segment of 14 Simbu serogroup viruses and partial nucleotide sequence determination of the G2 glycoprotein-coding region (encoded by the medium RNA segment) of 19 viruses. The overall phylogeny of the Simbu serogroup inferred from analyses of the N gene was similar to that inferred from analyses of the G2 protein-coding region. Both analyses revealed that the Simbu serogroup viruses have evolved into at least five major phylogenetic lineages. In general, these phylogenetic lineages were consistent with the previous serological data, but provided a more detailed understanding of the relatedness amongst many viruses. In comparison to previous phylogenetic studies on the California and Bunyamwera serogroups of the Bunyavirus genus, the Simbu serogroup displays much larger genetic variation in the N gene (up to 40% amino acid sequence divergence).

Original languageEnglish (US)
Pages (from-to)2173-2181
Number of pages9
JournalJournal of General Virology
Volume82
Issue number9
StatePublished - 2001

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Orthobunyavirus
Phylogeny
Simbu virus
Viruses
Sequence Analysis
Bunyaviridae
Genes
Nucleocapsid
Serogroup
Open Reading Frames
Amino Acid Sequence
Glycoproteins
RNA

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Phylogeny of the Simbu serogroup of the genus Bunyavirus. / Saeed, M. F.; Li, L.; Wang, H.; Weaver, Scott; Barrett, Alan.

In: Journal of General Virology, Vol. 82, No. 9, 2001, p. 2173-2181.

Research output: Contribution to journalArticle

Saeed, M. F. ; Li, L. ; Wang, H. ; Weaver, Scott ; Barrett, Alan. / Phylogeny of the Simbu serogroup of the genus Bunyavirus. In: Journal of General Virology. 2001 ; Vol. 82, No. 9. pp. 2173-2181.
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