TY - JOUR
T1 - Physical Heterogeneity of Bovine Gamma Globulins
T2 - Gamma-1M Globulin Electrophoretic Heterogeneity
AU - Murphy, Frederick A.
AU - Aalund, Ole
AU - Osebold, John W.
N1 - Funding Information:
This investigation was supported in part by a U.S.P.H.S. Postdoctoral Fellowship from Nat. Inst. of Allergy & Infect. Dis.
PY - 1964/11
Y1 - 1964/11
N2 - In the bovine species, gamma-1M globulin occurs as an electrophoretic continuum with most molecules of near mean mobility. No electrophoretic sub-groups of particularly high concentration, as described for 7S gamma globulins, were noted. Complement-fixing antibody activity was associated with bovine gamma-1M globulin molecules whose mean electrophoretic mobility was slower than the mean mobility of the protein as a whole. The marginal extent of this manifestation argues against anticipation of as heterogeneous a distribution of particular biological activities within the gamma-1M globulin spectrum as has been shown to be the case with 7S gamma globulins.
AB - In the bovine species, gamma-1M globulin occurs as an electrophoretic continuum with most molecules of near mean mobility. No electrophoretic sub-groups of particularly high concentration, as described for 7S gamma globulins, were noted. Complement-fixing antibody activity was associated with bovine gamma-1M globulin molecules whose mean electrophoretic mobility was slower than the mean mobility of the protein as a whole. The marginal extent of this manifestation argues against anticipation of as heterogeneous a distribution of particular biological activities within the gamma-1M globulin spectrum as has been shown to be the case with 7S gamma globulins.
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U2 - 10.3181/00379727-117-29624
DO - 10.3181/00379727-117-29624
M3 - Article
C2 - 14233483
AN - SCOPUS:78651148494
SN - 0037-9727
VL - 117
SP - 513
EP - 517
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -