Physical Heterogeneity of Bovine Gamma Globulins: Gamma-1M Globulin Electrophoretic Heterogeneity

Frederick A. Murphy, Ole Aalund, John W. Osebold

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In the bovine species, gamma-1M globulin occurs as an electrophoretic continuum with most molecules of near mean mobility. No electrophoretic sub-groups of particularly high concentration, as described for 7S gamma globulins, were noted. Complement-fixing antibody activity was associated with bovine gamma-1M globulin molecules whose mean electrophoretic mobility was slower than the mean mobility of the protein as a whole. The marginal extent of this manifestation argues against anticipation of as heterogeneous a distribution of particular biological activities within the gamma-1M globulin spectrum as has been shown to be the case with 7S gamma globulins.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Nov 1964
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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