Physical, metabolic, and hormonal effects on men of long-term therapy with medroxyprogesterone acetate

Walter Meyer, P. A. Walker, L. E. Emory, E. R. Smith

Research output: Contribution to journalArticle

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Abstract

Twenty-three men were treated with injectable medroxyprogesterone acetate (MPA) for sex-offending behavior. The physical, hormonal, and metabolic effects were monitored. The patients had significant (P < 0.001) weight gain and increases (P < 0.0001) in systolic blood pressure independent of weight gain, MPA therapy decreased testosterone (P < 0.0001), luteinizing hormone (P < 0.005), and testicular size (P < 0.001), but not follicle-stimulating hormone, MPA's suppression of total sperm count was not consistent, but MPA significantly reduced sperm motility (P < 0.001) and percent normal morphology (P < 0.005). Statistically insignificant increases in insulin response without changes in glucose tolerance occurred in all patients, but only one patient developed overt diabetes mellitus. Three men developed gallstones, but none had significant changes in liver function. Patients receiving high-dose MPA therapy should be carefully monitored for blood pressure changes, diabetes mellitus, and gallbladder dysfunction.

Original languageEnglish (US)
Pages (from-to)102-109
Number of pages8
JournalFertility and Sterility
Volume43
Issue number1
StatePublished - 1985

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Medroxyprogesterone Acetate
Blood Pressure
Weight Gain
Diabetes Mellitus
Sperm Count
Sperm Motility
Follicle Stimulating Hormone
Gallstones
Therapeutics
Luteinizing Hormone
Gallbladder
Sexual Behavior
Testosterone
Insulin
Glucose
Injections
Liver

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Physical, metabolic, and hormonal effects on men of long-term therapy with medroxyprogesterone acetate. / Meyer, Walter; Walker, P. A.; Emory, L. E.; Smith, E. R.

In: Fertility and Sterility, Vol. 43, No. 1, 1985, p. 102-109.

Research output: Contribution to journalArticle

Meyer, W, Walker, PA, Emory, LE & Smith, ER 1985, 'Physical, metabolic, and hormonal effects on men of long-term therapy with medroxyprogesterone acetate', Fertility and Sterility, vol. 43, no. 1, pp. 102-109.
Meyer, Walter ; Walker, P. A. ; Emory, L. E. ; Smith, E. R. / Physical, metabolic, and hormonal effects on men of long-term therapy with medroxyprogesterone acetate. In: Fertility and Sterility. 1985 ; Vol. 43, No. 1. pp. 102-109.
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