Physical, metabolic, and hormonal effects on men of long-term therapy with medroxyprogesterone acetate

W. J. Meyer, P. A. Walker, L. E. Emory, E. R. Smith

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Twenty-three men were treated with injectable medroxyprogesterone acetate (MPA) for sex-offending behavior. The physical, hormonal, and metabolic effects were monitored. The patients had significant (P < 0.001) weight gain and increases (P < 0.0001) in systolic blood pressure independent of weight gain, MPA therapy decreased testosterone (P < 0.0001), luteinizing hormone (P < 0.005), and testicular size (P < 0.001), but not follicle-stimulating hormone, MPA's suppression of total sperm count was not consistent, but MPA significantly reduced sperm motility (P < 0.001) and percent normal morphology (P < 0.005). Statistically insignificant increases in insulin response without changes in glucose tolerance occurred in all patients, but only one patient developed overt diabetes mellitus. Three men developed gallstones, but none had significant changes in liver function. Patients receiving high-dose MPA therapy should be carefully monitored for blood pressure changes, diabetes mellitus, and gallbladder dysfunction.

Original languageEnglish (US)
Pages (from-to)102-109
Number of pages8
JournalFertility and Sterility
Volume43
Issue number1
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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