Physicians' attitudes towards and reasons for participation in the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial

Mahbubur Rahman, Satoshi Morita, Tsuguya Fukui, Junichi Sakamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Physicians' perception and attitudes towards a research topic and trial management could influence their participation in a randomized controlled trial. The objectives of this study were to determine the reasons for physicians' participation in and attitudes towards the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial. Methods: CASE-J's main objective is to compare the effectiveness of an angiotensin 11 receptor antagonist (candesartan cilexetil) with that of a calcium channel blocker (amlodipine besilate) in terms of the incidence of cardiovascular events among high-risk hypertensive patients. We conducted a questionnaire survey among the physicians (n=512) participating in that trial to determine the reasons behind their participation and to elicit their reactions to the trial management. Results: Eighty-eight percent of the 512 participating physicians responded to our survey. The main reasons for participation were clear objectives of the trial (85.1 %), a simple protocol (61.1 %), interest in finding out the inhibiting effects of the drugs on cardiac events (80.2%), and a well-organized support system (59.8%). As for negative factors, case registration and follow-up were considered cumbersome by 28.6% and 10.8%, respectively while 44.2% stated that support by the clinical research coordinators provided by the trial management authority was necessary for case screening, recruitment process, patient registration, and follow-up. Multivariate logistic regression analysis showed that participants who did not use a computer very regularly (odds ratio = 1.9, 95% confidence interval = 1.1-3.6) were more likely to consider the case registration and follow-up procedures as a cumbersome. Conclusion: The information generated by this study could be useful in designing future randomized controlled trials in Japan and abroad.

Original languageEnglish (US)
Pages (from-to)38-40
Number of pages3
JournalJournal of Epidemiology
Volume15
Issue number2
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Antihypertensive Agents
Japan
Physicians
Survival
Randomized Controlled Trials
Amlodipine
Angiotensin Receptor Antagonists
Calcium Channel Blockers
Research
Patient Selection
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
candesartan
Incidence
Pharmaceutical Preparations
Surveys and Questionnaires

Keywords

  • Data collection
  • Database management systems
  • Information systems
  • Physicians
  • Randomized controlled trials

ASJC Scopus subject areas

  • Epidemiology

Cite this

Physicians' attitudes towards and reasons for participation in the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial. / Rahman, Mahbubur; Morita, Satoshi; Fukui, Tsuguya; Sakamoto, Junichi.

In: Journal of Epidemiology, Vol. 15, No. 2, 2005, p. 38-40.

Research output: Contribution to journalArticle

Rahman, Mahbubur ; Morita, Satoshi ; Fukui, Tsuguya ; Sakamoto, Junichi. / Physicians' attitudes towards and reasons for participation in the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial. In: Journal of Epidemiology. 2005 ; Vol. 15, No. 2. pp. 38-40.
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