Physico-chemical properties of low density lipoproteins in normolipidemic Asian Indian men

N. Abate, A. Garg, E. A. Enas

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The present study investigated whether a predisposition to high frequency of small, dense low density lipoproteins (LDL) could be an additional coronary risk factor in migrant Asian Indians. Ninety-three normolipidemic (fasting plasma cholesterol levels ≤ 240 mg/dl and triglyceride levels ≤ 250 mg/dl) adult Asian Indian men residing in the U.S. were compared to a group of 59 Caucasian men for the prevalence of LDL electrophoretic patterns A and B (size of major LDL peak ≥ 255 Å for LDL pattern A and < 255 Å for LDL pattern B). Compared to the Caucasians, the Asian Indians had larger LDL size (mean ± SD; 260.1 ± 12.8 Å vs 267.7 ± 11.4 Å, respectively; p = 0.0002), an increased frequency of LDL pattern A (59% vs 85%, respectively) and a lower frequency of LDL pattern B (41% vs 15%, respectively) (p = 0.0005). The difference in LDL size in the two study groups persisted after adjusting for the various confounding variables, such as age, plasma triglycerides, high-density lipoprotein cholesterol and dietary habits. We conclude that compared to Caucasians, Asian Indian men have larger LDL particles and a lower prevalence of LDL phenotype B in the presence of normolipidemia. Therefore, we exclude a genetic predisposition to atherogenic LDL phenotype as a factor contributing to the high incidence of coronary heart disease in migrant Asian Indians.

Original languageEnglish (US)
Pages (from-to)326-331
Number of pages6
JournalHormone and Metabolic Research
Volume27
Issue number7
DOIs
StatePublished - Jan 1 1995

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Keywords

  • Coronary Heart Disease
  • Diet
  • Ethnicity
  • India
  • LDL Patterns
  • Lipoprotein

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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