Abstract
The present study investigated whether a predisposition to high frequency of small, dense low density lipoproteins (LDL) could be an additional coronary risk factor in migrant Asian Indians. Ninety-three normolipidemic (fasting plasma cholesterol levels ≤ 240 mg/dl and triglyceride levels ≤ 250 mg/dl) adult Asian Indian men residing in the U.S. were compared to a group of 59 Caucasian men for the prevalence of LDL electrophoretic patterns A and B (size of major LDL peak ≥ 255 Å for LDL pattern A and < 255 Å for LDL pattern B). Compared to the Caucasians, the Asian Indians had larger LDL size (mean ± SD; 260.1 ± 12.8 Å vs 267.7 ± 11.4 Å, respectively; p = 0.0002), an increased frequency of LDL pattern A (59% vs 85%, respectively) and a lower frequency of LDL pattern B (41% vs 15%, respectively) (p = 0.0005). The difference in LDL size in the two study groups persisted after adjusting for the various confounding variables, such as age, plasma triglycerides, high-density lipoprotein cholesterol and dietary habits. We conclude that compared to Caucasians, Asian Indian men have larger LDL particles and a lower prevalence of LDL phenotype B in the presence of normolipidemia. Therefore, we exclude a genetic predisposition to atherogenic LDL phenotype as a factor contributing to the high incidence of coronary heart disease in migrant Asian Indians.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 326-331 |
| Number of pages | 6 |
| Journal | Hormone and Metabolic Research |
| Volume | 27 |
| Issue number | 7 |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- Coronary Heart Disease
- Diet
- Ethnicity
- India
- LDL Patterns
- Lipoprotein
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Physico-chemical properties of low density lipoproteins in normolipidemic Asian Indian men. / Abate, Nicola; Garg, A.; Enas, E. A.
In: Hormone and Metabolic Research, Vol. 27, No. 7, 1995, p. 326-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physico-chemical properties of low density lipoproteins in normolipidemic Asian Indian men
AU - Abate, Nicola
AU - Garg, A.
AU - Enas, E. A.
PY - 1995
Y1 - 1995
N2 - The present study investigated whether a predisposition to high frequency of small, dense low density lipoproteins (LDL) could be an additional coronary risk factor in migrant Asian Indians. Ninety-three normolipidemic (fasting plasma cholesterol levels ≤ 240 mg/dl and triglyceride levels ≤ 250 mg/dl) adult Asian Indian men residing in the U.S. were compared to a group of 59 Caucasian men for the prevalence of LDL electrophoretic patterns A and B (size of major LDL peak ≥ 255 Å for LDL pattern A and < 255 Å for LDL pattern B). Compared to the Caucasians, the Asian Indians had larger LDL size (mean ± SD; 260.1 ± 12.8 Å vs 267.7 ± 11.4 Å, respectively; p = 0.0002), an increased frequency of LDL pattern A (59% vs 85%, respectively) and a lower frequency of LDL pattern B (41% vs 15%, respectively) (p = 0.0005). The difference in LDL size in the two study groups persisted after adjusting for the various confounding variables, such as age, plasma triglycerides, high-density lipoprotein cholesterol and dietary habits. We conclude that compared to Caucasians, Asian Indian men have larger LDL particles and a lower prevalence of LDL phenotype B in the presence of normolipidemia. Therefore, we exclude a genetic predisposition to atherogenic LDL phenotype as a factor contributing to the high incidence of coronary heart disease in migrant Asian Indians.
AB - The present study investigated whether a predisposition to high frequency of small, dense low density lipoproteins (LDL) could be an additional coronary risk factor in migrant Asian Indians. Ninety-three normolipidemic (fasting plasma cholesterol levels ≤ 240 mg/dl and triglyceride levels ≤ 250 mg/dl) adult Asian Indian men residing in the U.S. were compared to a group of 59 Caucasian men for the prevalence of LDL electrophoretic patterns A and B (size of major LDL peak ≥ 255 Å for LDL pattern A and < 255 Å for LDL pattern B). Compared to the Caucasians, the Asian Indians had larger LDL size (mean ± SD; 260.1 ± 12.8 Å vs 267.7 ± 11.4 Å, respectively; p = 0.0002), an increased frequency of LDL pattern A (59% vs 85%, respectively) and a lower frequency of LDL pattern B (41% vs 15%, respectively) (p = 0.0005). The difference in LDL size in the two study groups persisted after adjusting for the various confounding variables, such as age, plasma triglycerides, high-density lipoprotein cholesterol and dietary habits. We conclude that compared to Caucasians, Asian Indian men have larger LDL particles and a lower prevalence of LDL phenotype B in the presence of normolipidemia. Therefore, we exclude a genetic predisposition to atherogenic LDL phenotype as a factor contributing to the high incidence of coronary heart disease in migrant Asian Indians.
KW - Coronary Heart Disease
KW - Diet
KW - Ethnicity
KW - India
KW - LDL Patterns
KW - Lipoprotein
UR - http://www.scopus.com/inward/record.url?scp=0029100995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029100995&partnerID=8YFLogxK
M3 - Article
C2 - 7590616
AN - SCOPUS:0029100995
VL - 27
SP - 326
EP - 331
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 7
ER -