Abstract
The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-230 |
| Number of pages | 13 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Physicochemical factors in maternal-fetal distribution of drugs. / Maickel, Roger P.; Snodgrass, Wayne R.
In: Toxicology and Applied Pharmacology, Vol. 26, No. 2, 1973, p. 218-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physicochemical factors in maternal-fetal distribution of drugs
AU - Maickel, Roger P.
AU - Snodgrass, Wayne R.
PY - 1973
Y1 - 1973
N2 - The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.
AB - The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015819750&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(73)90255-X
DO - 10.1016/0041-008X(73)90255-X
M3 - Article
VL - 26
SP - 218
EP - 230
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 2
ER -