Physicochemical factors in maternal-fetal distribution of drugs

Roger P. Maickel, Wayne R. Snodgrass

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.

Original languageEnglish (US)
Pages (from-to)218-230
Number of pages13
JournalToxicology and Applied Pharmacology
Volume26
Issue number2
DOIs
StatePublished - 1973
Externally publishedYes

Fingerprint

Mothers
Pharmaceutical Preparations
Rats
Tissue
Fetus
Plasmas

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Physicochemical factors in maternal-fetal distribution of drugs. / Maickel, Roger P.; Snodgrass, Wayne R.

In: Toxicology and Applied Pharmacology, Vol. 26, No. 2, 1973, p. 218-230.

Research output: Contribution to journalArticle

Maickel, Roger P. ; Snodgrass, Wayne R. / Physicochemical factors in maternal-fetal distribution of drugs. In: Toxicology and Applied Pharmacology. 1973 ; Vol. 26, No. 2. pp. 218-230.
@article{be87b2dc0fc74612a5427c3d39e8d2ce,
title = "Physicochemical factors in maternal-fetal distribution of drugs",
abstract = "The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.",
author = "Maickel, {Roger P.} and Snodgrass, {Wayne R.}",
year = "1973",
doi = "10.1016/0041-008X(73)90255-X",
language = "English (US)",
volume = "26",
pages = "218--230",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Physicochemical factors in maternal-fetal distribution of drugs

AU - Maickel, Roger P.

AU - Snodgrass, Wayne R.

PY - 1973

Y1 - 1973

N2 - The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.

AB - The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.

UR - http://www.scopus.com/inward/record.url?scp=0015819750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015819750&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(73)90255-X

DO - 10.1016/0041-008X(73)90255-X

M3 - Article

VL - 26

SP - 218

EP - 230

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -