@article{be87b2dc0fc74612a5427c3d39e8d2ce,
title = "Physicochemical factors in maternal-fetal distribution of drugs",
abstract = "The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.",
author = "Maickel, {Roger P.} and Snodgrass, {Wayne R.}",
note = "Funding Information: METHODS Pregnant female ARS Sprague-Dawley rats were obtained at IO-12 days of gestation and maintained ad libitum on a diet of Purina rat pellets and tap water until 1S -20 days 1 Supported in part by USPHS grants HD-03037, MH-14658, MH-18852 and K-02-MH-41083 (to R. P. Maickel). 2 Preliminary reports of these data have been presented: R. P. Maickel and J. M. Saillant, Pharmacologist 10, 153 (1968); R. P. Maickel and W. R. Snodgrass, 4th International Pharmacological Congress, Basle, Switzerland, July 1969. 3 Taken in part from a thesis submitted by W. R. Snodgrasst o the Graduate School in partial fulfillment of the requirements for the M.S. degree, Department of Pharmacology, Indiana University, 1970.",
year = "1973",
month = oct,
doi = "10.1016/0041-008X(73)90255-X",
language = "English (US)",
volume = "26",
pages = "218--230",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",
}