Physicochemical factors in maternal-fetal distribution of drugs

Roger P. Maickel, Wayne R. Snodgrass

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The time course of physiological disposition of a variety of drugs has been examined in pregnant rats using radiolabeled compounds and highly specific methods. The results indicate that the placental barrier in rats behaves as a lipoidal barrier towards positively charged and neutral drugs, while negatively charged drugs pass the placental barrier with comparative ease. Localization in fetal tissues is less pronounced that in corresponding maternal tissues for all drugs. Fetal and maternal plasma half-lives are similar for most of the compounds tested.

Original languageEnglish (US)
Pages (from-to)218-230
Number of pages13
JournalToxicology and Applied Pharmacology
Volume26
Issue number2
DOIs
StatePublished - Oct 1973

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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