TY - JOUR
T1 - Physiologic and psychologic symptoms associated with use of injectable contraception and 20 μg oral contraceptive pills
AU - Berenson, Abbey B.
AU - Odom, Susan D.
AU - Breitkopf, Carmen Radecki
AU - Rahman, Mahbubur
N1 - Funding Information:
This study was supported by grants R01HD39883 and K24HD043659 from the National Institute of Child Health and Human Development (to A.B.B.) and grant M01RR000073 from the General Clinical Research Centers program, National Center for Research Resources, National Institutes of Health.
PY - 2008/10
Y1 - 2008/10
N2 - Objective: The objective of the study was to compare menstrual, physiologic, and psychologic symptoms over 2 years among women initiating use of depot medroxyprogesterone acetate or an oral contraceptive pill with a reduced pill-free interval and those not using hormonal contraception. Study Design: A total of 608 women reported their experience regarding 17 symptoms prior to initiating contraception and every 6 months thereafter for 24 months. Longitudinal relationships between symptoms and contraceptives were assessed after adjusting for age, visits, and baseline status of symptoms. Results: Oral contraceptive pills were protective against mastalgia (odds ratio [OR], 0.7), cramping (OR, 0.5), hair loss (OR, 0.6), acne (OR, 0.4), nervousness (OR, 0.5), and mood swings (OR, 0.7). Depot medroxyprogesterone acetate (DMPA) was protective against bloating (OR, 0.5) and mood swings (OR, 0.7) but caused weight gain (OR, 2.3), bleeding episodes more than 20 days (OR, 13.4), and missed periods (OR, 96.9). Both methods caused intermenstrual bleeding. Conclusion: Evidence-based data regarding beneficial and adverse symptoms associated with these methods may help clinicians counsel patients appropriately prior to contraceptive initiation.
AB - Objective: The objective of the study was to compare menstrual, physiologic, and psychologic symptoms over 2 years among women initiating use of depot medroxyprogesterone acetate or an oral contraceptive pill with a reduced pill-free interval and those not using hormonal contraception. Study Design: A total of 608 women reported their experience regarding 17 symptoms prior to initiating contraception and every 6 months thereafter for 24 months. Longitudinal relationships between symptoms and contraceptives were assessed after adjusting for age, visits, and baseline status of symptoms. Results: Oral contraceptive pills were protective against mastalgia (odds ratio [OR], 0.7), cramping (OR, 0.5), hair loss (OR, 0.6), acne (OR, 0.4), nervousness (OR, 0.5), and mood swings (OR, 0.7). Depot medroxyprogesterone acetate (DMPA) was protective against bloating (OR, 0.5) and mood swings (OR, 0.7) but caused weight gain (OR, 2.3), bleeding episodes more than 20 days (OR, 13.4), and missed periods (OR, 96.9). Both methods caused intermenstrual bleeding. Conclusion: Evidence-based data regarding beneficial and adverse symptoms associated with these methods may help clinicians counsel patients appropriately prior to contraceptive initiation.
KW - birth control
KW - contraception
KW - depot medroxyprogesterone acetate
KW - oral contraceptive pills
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U2 - 10.1016/j.ajog.2008.04.048
DO - 10.1016/j.ajog.2008.04.048
M3 - Article
C2 - 18599013
AN - SCOPUS:52949090775
VL - 199
SP - 351.e1-351.e12
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -