Physiologic and psychologic symptoms associated with use of injectable contraception and 20 μg oral contraceptive pills

Abbey Berenson, Susan D. Odom, Carmen Radecki Breitkopf, Mahbubur Rahman

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: The objective of the study was to compare menstrual, physiologic, and psychologic symptoms over 2 years among women initiating use of depot medroxyprogesterone acetate or an oral contraceptive pill with a reduced pill-free interval and those not using hormonal contraception. Study Design: A total of 608 women reported their experience regarding 17 symptoms prior to initiating contraception and every 6 months thereafter for 24 months. Longitudinal relationships between symptoms and contraceptives were assessed after adjusting for age, visits, and baseline status of symptoms. Results: Oral contraceptive pills were protective against mastalgia (odds ratio [OR], 0.7), cramping (OR, 0.5), hair loss (OR, 0.6), acne (OR, 0.4), nervousness (OR, 0.5), and mood swings (OR, 0.7). Depot medroxyprogesterone acetate (DMPA) was protective against bloating (OR, 0.5) and mood swings (OR, 0.7) but caused weight gain (OR, 2.3), bleeding episodes more than 20 days (OR, 13.4), and missed periods (OR, 96.9). Both methods caused intermenstrual bleeding. Conclusion: Evidence-based data regarding beneficial and adverse symptoms associated with these methods may help clinicians counsel patients appropriately prior to contraceptive initiation.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number4
DOIs
StatePublished - Oct 2008

Fingerprint

Oral Contraceptives
Contraception
Odds Ratio
Injections
Medroxyprogesterone Acetate
Contraceptive Agents
Mastodynia
Metrorrhagia
Alopecia
Acne Vulgaris
Weight Gain
Anxiety
Hemorrhage

Keywords

  • birth control
  • contraception
  • depot medroxyprogesterone acetate
  • oral contraceptive pills

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Physiologic and psychologic symptoms associated with use of injectable contraception and 20 μg oral contraceptive pills. / Berenson, Abbey; Odom, Susan D.; Breitkopf, Carmen Radecki; Rahman, Mahbubur.

In: American Journal of Obstetrics and Gynecology, Vol. 199, No. 4, 10.2008.

Research output: Contribution to journalArticle

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