Abstract
Human pregnancy is characterized by profound anatomic and physiologic changes that affect virtually all systems and organs in the body. Many of these changes begin in early gestation. Understanding of the various physiologic adaptations in pregnancy is vital to the clinician and the pharmacologist as many of these alterations will have a significant impact on pharmacokinetics and pharmacodynamics of different therapeutic agents. A typical example involves the increase in glomerular filtration rate during pregnancy leading to increased clearance of heparins, thus requiring the use of higher doses during pregnancy. This chapter discusses the most relevant physiologic changes that occur during human gestation.
Original language | English (US) |
---|---|
Title of host publication | Clinical Pharmacology During Pregnancy |
Publisher | Elsevier |
Pages | 5-17 |
Number of pages | 13 |
ISBN (Electronic) | 9780128189023 |
DOIs | |
State | Published - Jan 1 2021 |
Keywords
- Physiologic changes during pregnancy
- Summary of cardiovascular changes during pregnancy
- Summary of hematologic changes in pregnancy
- Summary of renal changes in pregnancy
- Summary of respiratory changes in pregnancy
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Medicine