Physiologic changes during pregnancy

Mahmoud Abdelwahab, Maged M. Costantine, Luis Pacheco

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Human pregnancy is characterized by profound anatomic and physiologic changes that affect virtually all systems and organs in the body. Many of these changes begin in early gestation. Understanding of the various physiologic adaptations in pregnancy is vital to the clinician and the pharmacologist as many of these alterations will have a significant impact on pharmacokinetics and pharmacodynamics of different therapeutic agents. A typical example involves the increase in glomerular filtration rate during pregnancy leading to increased clearance of heparins, thus requiring the use of higher doses during pregnancy. This chapter discusses the most relevant physiologic changes that occur during human gestation.

Original languageEnglish (US)
Title of host publicationClinical Pharmacology During Pregnancy
Number of pages13
ISBN (Electronic)9780128189023
StatePublished - Jan 1 2021


  • Physiologic changes during pregnancy
  • Summary of cardiovascular changes during pregnancy
  • Summary of hematologic changes in pregnancy
  • Summary of renal changes in pregnancy
  • Summary of respiratory changes in pregnancy

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Medicine


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