Physiologic role of cholecystokinin in the intestinal phase of pancreatic polypeptide release

G. M. Fried, W. D. Ogden, G. H. Greeley, J. C. Thompson

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Abstract

Release of pancreatic polypeptide (PP) after a meal is biphasic, with an early transient peak believed to be under cholinergic control, and a secondary, prolonged intestinal phase thought to be mediated by hormones. Endogenous release of PP was stimulated by intraduodenal oleate (6.8 mmol/hr) or by intravenous administration of pure cholecystokinin-33 (CCK-33, 0.1 μg/kg/hr) in five dogs. Radioimmunoassay measurements of plasma concentrations of PP and CCK-33 were compared by linear regression analysis before and after vagotomy. Correlations between plasma concentrations of PP and CCK-33 before vagotomy (r = 0.83 [oleate], r = 0.97 [IV-CCK-33]) and after vagotomy (r = 0.92 [oleate], r = 0.92 [IV-CCK-33]) were highly significant. Changes in plasma concentrations of PP relative to a particular increment in plasma CCK-33 (before vagotomy) were similar, whether stimulated by oleate or by exogenous CCK-33. After vagotomy, less PP was released relative to a change in plasma CCK-33 (stimulated by oleate or by exogenous CCK-33), but the PP response relative to a change in plasma CCK-33 induced by the two stimuli remained remarkably similar. These results provide evidence that the intestinal phase of physiologic release of PP is mediated to a large extent through release of CCK.

Original languageEnglish (US)
Pages (from-to)600-604
Number of pages5
JournalAnnals of Surgery
Volume200
Issue number5
StatePublished - 1984

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ASJC Scopus subject areas

  • Surgery

Cite this

Fried, G. M., Ogden, W. D., Greeley, G. H., & Thompson, J. C. (1984). Physiologic role of cholecystokinin in the intestinal phase of pancreatic polypeptide release. Annals of Surgery, 200(5), 600-604.