Physiology of the vasopressin receptors

Marc O. Maybauer; Dirk M. Maybauer; Perenlei Enkhbaatar; Daniel L. Traber

doi:10.1016/j.bpa.2008.03.003

Physiology of the vasopressin receptors

Marc O. Maybauer, Dirk M. Maybauer, Perenlei Enkhbaatar, Daniel L. Traber

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

This review article summarizes the structure, signalling pathways, and tissue distribution of the vasopressin receptors, V₁ vascular, V₂ renal, V₃ pituitary, and oxytocin receptors, as well as the P₂ class of purinoceptors. The physiological effects of vasopressin on its receptors are described. The future direction with regard to the role of the V_1a receptor in circulatory shock states is discussed; further studies with V_1a receptor agonists are warranted to further develop treatment strategies to reduce mortality in life threatening diseases like septic shock.

Original language	English (US)
Pages (from-to)	253-263
Number of pages	11
Journal	Best Practice and Research: Clinical Anaesthesiology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.bpa.2008.03.003
State	Published - Jun 2008

Keywords

V1 receptor agonist
amino acid sequences
arginine-vasopressin (AVP)
hypovolemia
oxytocin (ot)
sepsis
vasopressin
vasopressin (VP)

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1016/j.bpa.2008.03.003

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title = "Physiology of the vasopressin receptors",

abstract = "This review article summarizes the structure, signalling pathways, and tissue distribution of the vasopressin receptors, V1 vascular, V2 renal, V3 pituitary, and oxytocin receptors, as well as the P2 class of purinoceptors. The physiological effects of vasopressin on its receptors are described. The future direction with regard to the role of the V1a receptor in circulatory shock states is discussed; further studies with V1a receptor agonists are warranted to further develop treatment strategies to reduce mortality in life threatening diseases like septic shock.",

keywords = "V1 receptor agonist, amino acid sequences, arginine-vasopressin (AVP), hypovolemia, oxytocin (ot), sepsis, vasopressin, vasopressin (VP)",

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AU - Maybauer, Marc O.

AU - Maybauer, Dirk M.

AU - Enkhbaatar, Perenlei

AU - Traber, Daniel L.

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AB - This review article summarizes the structure, signalling pathways, and tissue distribution of the vasopressin receptors, V1 vascular, V2 renal, V3 pituitary, and oxytocin receptors, as well as the P2 class of purinoceptors. The physiological effects of vasopressin on its receptors are described. The future direction with regard to the role of the V1a receptor in circulatory shock states is discussed; further studies with V1a receptor agonists are warranted to further develop treatment strategies to reduce mortality in life threatening diseases like septic shock.

KW - V1 receptor agonist

KW - amino acid sequences

KW - arginine-vasopressin (AVP)

KW - hypovolemia

KW - oxytocin (ot)

KW - sepsis

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KW - vasopressin (VP)

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Physiology of the vasopressin receptors

Abstract

Keywords

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