Phytochemical and pharmacological evaluation of fruits of Solanum indicum linn

Prashanta Kr Deb, Ranjib Ghosh, Raja Chakraverty, Rajkumar Debnath, Lakshman Das, Tejendra Bhakta

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The present study focused on the preliminary phytochemical screening and pharmacological evaluation of the dried fruit extract of Solanum indicum Linn. on experimental animal models of a variety of ailments viz. pain, fever, inflammation and CNS complication. The acute toxicity study as per OECD guidelines 423 revealed the drug to be safe till a dose of 2000 mg/kg. Adult Wistar albino rats (180-200 gm) of either sex were used for the study and subdivided into four (4) groups (n=6). The extract was evaluated for its analgesic, anti-inflammatory, antipyretic and CNS depressant activity. Statistical analysis was done through one way ANOVA followed by post hoc Tukey's multiple comparison tests. Phytochemical screening of MeOH extract revealed the presence of flavonoids, steroid, tannin, glycosides and saponins among other constituents. The main findings depicted that the crude MeOH extract of the dried fruits of Solanum indicum Linn. Exhibited statistically significant analgesic (P ≤ 0.05), antipyretic (P ≤ 0.05), analgesic (P ≤ 0.05) and CNS depressant activity (P ≤ 0.05) on the established animal models. Experimental evidences lead to the hypothesis that MeOH extract of Solanum indicum Linn. fruit possesses pharmacological activity which satisfies the claim of traditional medicinal uses.

Original languageEnglish (US)
Article number06
Pages (from-to)28-32
Number of pages5
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume25
Issue number2
StatePublished - 2014
Externally publishedYes

Keywords

  • Analgesic
  • Anti-inflammatory
  • Antipyretic
  • CNS depressant activity
  • Fruit
  • Solanum indicum linn

ASJC Scopus subject areas

  • Pharmaceutical Science

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