Abstract
Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1391-1396 |
| Number of pages | 6 |
| Journal | Archives of virology |
| Volume | 153 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2008 |
ASJC Scopus subject areas
- Virology
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Vela, E. M., Colpitts, T. M., Zhang, L., Davey, R. A., & Aronson, J. F. (2008). Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes. Archives of virology, 153(7), 1391-1396. https://doi.org/10.1007/s00705-008-0129-3