Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Eric M. Vela, Tonya M. Colpitts, Lihong Zhang, Robert A. Davey, Judith Aronson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

Original languageEnglish (US)
Pages (from-to)1391-1396
Number of pages6
JournalArchives of Virology
Volume153
Issue number7
DOIs
StatePublished - Jul 2008

Fingerprint

Dynamin II
Endosomes
Viruses
New World Arenaviruses
Arenavirus
Virus Internalization
Clathrin

ASJC Scopus subject areas

  • Genetics
  • Applied Microbiology and Biotechnology

Cite this

Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes. / Vela, Eric M.; Colpitts, Tonya M.; Zhang, Lihong; Davey, Robert A.; Aronson, Judith.

In: Archives of Virology, Vol. 153, No. 7, 07.2008, p. 1391-1396.

Research output: Contribution to journalArticle

Vela, Eric M. ; Colpitts, Tonya M. ; Zhang, Lihong ; Davey, Robert A. ; Aronson, Judith. / Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes. In: Archives of Virology. 2008 ; Vol. 153, No. 7. pp. 1391-1396.
@article{93eedf4e362a43be8d5b945dd2608ddc,
title = "Pichind{\'e} virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes",
abstract = "Pichind{\'e} virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.",
author = "Vela, {Eric M.} and Colpitts, {Tonya M.} and Lihong Zhang and Davey, {Robert A.} and Judith Aronson",
year = "2008",
month = "7",
doi = "10.1007/s00705-008-0129-3",
language = "English (US)",
volume = "153",
pages = "1391--1396",
journal = "Archives of Virology",
issn = "0304-8608",
publisher = "Springer Wien",
number = "7",

}

TY - JOUR

T1 - Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

AU - Vela, Eric M.

AU - Colpitts, Tonya M.

AU - Zhang, Lihong

AU - Davey, Robert A.

AU - Aronson, Judith

PY - 2008/7

Y1 - 2008/7

N2 - Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

AB - Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

UR - http://www.scopus.com/inward/record.url?scp=45849110264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45849110264&partnerID=8YFLogxK

U2 - 10.1007/s00705-008-0129-3

DO - 10.1007/s00705-008-0129-3

M3 - Article

VL - 153

SP - 1391

EP - 1396

JO - Archives of Virology

JF - Archives of Virology

SN - 0304-8608

IS - 7

ER -