Abstract
Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1391-1396 |
| Number of pages | 6 |
| Journal | Archives of Virology |
| Volume | 153 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2008 |
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ASJC Scopus subject areas
- Genetics
- Applied Microbiology and Biotechnology
Cite this
Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes. / Vela, Eric M.; Colpitts, Tonya M.; Zhang, Lihong; Davey, Robert A.; Aronson, Judith.
In: Archives of Virology, Vol. 153, No. 7, 07.2008, p. 1391-1396.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes
AU - Vela, Eric M.
AU - Colpitts, Tonya M.
AU - Zhang, Lihong
AU - Davey, Robert A.
AU - Aronson, Judith
PY - 2008/7
Y1 - 2008/7
N2 - Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.
AB - Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.
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UR - http://www.scopus.com/inward/citedby.url?scp=45849110264&partnerID=8YFLogxK
U2 - 10.1007/s00705-008-0129-3
DO - 10.1007/s00705-008-0129-3
M3 - Article
VL - 153
SP - 1391
EP - 1396
JO - Archives of Virology
JF - Archives of Virology
SN - 0304-8608
IS - 7
ER -