Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Eric M. Vela; Tonya M. Colpitts; Lihong Zhang; Robert A. Davey; Judith F. Aronson

doi:10.1007/s00705-008-0129-3

Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Eric M. Vela, Tonya M. Colpitts, Lihong Zhang, Robert A. Davey, Judith F. Aronson

Pathology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

Original language	English (US)
Pages (from-to)	1391-1396
Number of pages	6
Journal	Archives of virology
Volume	153
Issue number	7
DOIs	https://doi.org/10.1007/s00705-008-0129-3
State	Published - Jul 2008

ASJC Scopus subject areas

Virology

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10.1007/s00705-008-0129-3

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title = "Pichind{\'e} virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes",

abstract = "Pichind{\'e} virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.",

author = "Vela, {Eric M.} and Colpitts, {Tonya M.} and Lihong Zhang and Davey, {Robert A.} and Aronson, {Judith F.}",

note = "Funding Information: We would like to thank Eugene Knutson for his assistance with confocal microscopy. This work was supported by the NIAID Training in Emerging and Reemerging Infectious Diseases T32 AI007536. Robert A. Davey is supported by grants from NIAID 1R01AI063513-01A2 and U54 AI057156.",

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doi = "10.1007/s00705-008-0129-3",

language = "English (US)",

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T1 - Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

AU - Vela, Eric M.

AU - Colpitts, Tonya M.

AU - Zhang, Lihong

AU - Davey, Robert A.

AU - Aronson, Judith F.

N1 - Funding Information: We would like to thank Eugene Knutson for his assistance with confocal microscopy. This work was supported by the NIAID Training in Emerging and Reemerging Infectious Diseases T32 AI007536. Robert A. Davey is supported by grants from NIAID 1R01AI063513-01A2 and U54 AI057156.

PY - 2008/7

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N2 - Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

AB - Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

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Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Abstract

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