Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Eric M. Vela; Tonya M. Colpitts; Lihong Zhang; Robert A. Davey; Judith F. Aronson

doi:10.1007/s00705-008-0129-3

Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Eric M. Vela, Tonya M. Colpitts, Lihong Zhang, Robert A. Davey, Judith F. Aronson

Pathology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

Original language	English (US)
Pages (from-to)	1391-1396
Number of pages	6
Journal	Archives of virology
Volume	153
Issue number	7
DOIs	https://doi.org/10.1007/s00705-008-0129-3
State	Published - Jul 2008

ASJC Scopus subject areas

Virology

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abstract = "Pichind{\'e} virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.",

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AU - Vela, Eric M.

AU - Colpitts, Tonya M.

AU - Zhang, Lihong

AU - Davey, Robert A.

AU - Aronson, Judith F.

PY - 2008/7

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AB - Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

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