Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Eric M. Vela, Tonya M. Colpitts, Lihong Zhang, Robert A. Davey, Judith F. Aronson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.

Original languageEnglish (US)
Pages (from-to)1391-1396
Number of pages6
JournalArchives of virology
Volume153
Issue number7
DOIs
StatePublished - Jul 1 2008

ASJC Scopus subject areas

  • Virology

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