Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer

Kamyar Ghabili, Paul S. Agutter, Mohammadali Mohajel Shoja

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Electromagnetic fields (EMF) may contribute to the pathogenesis of prostate cancer, but the mechanism is obscure. Numerous calcium/phosphorus crystalloids with various morphologies have been found in the normal prostate gland and in both benign and malignant prostate lesions. Their distribution within the gland is heterogeneous and diffuse. We propose that an environmental EMF may exert a piezoelectric effect on these crystalloids, resulting in simultaneous, multidirectional and diffuse compression or expansion and consequently a slight mechanical distortion of the prostate. Such distortion is known to alter gene expression in many kinds of cells and therefore cell phenotype; such alterations can suppress apoptosis. In this paper we explore the scientific and clinical evidence favoring this hypothesis and present a mathematical model of the proposed cell-mechanical effect.

Original languageEnglish (US)
Title of host publicationHandbook of Prostate Cancer Cell Research
Subtitle of host publicationGrowth, Signalling, and Survival
PublisherNova Science Publishers, Inc.
Pages507-514
Number of pages8
ISBN (Print)9781607419549
StatePublished - Dec 1 2009
Externally publishedYes

Fingerprint

Electromagnetic Fields
Electromagnetic fields
Prostate
Prostatic Neoplasms
Piezoelectricity
Gene expression
Phosphorus
Mathematical models
Apoptosis
Calcium
Theoretical Models
Phenotype
Gene Expression
crystalloid solutions

Keywords

  • Cell mechanics
  • Crystalloid
  • Electromagnetic field
  • Piezoelectric effect
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ghabili, K., Agutter, P. S., & Mohajel Shoja, M. (2009). Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer. In Handbook of Prostate Cancer Cell Research: Growth, Signalling, and Survival (pp. 507-514). Nova Science Publishers, Inc..

Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer. / Ghabili, Kamyar; Agutter, Paul S.; Mohajel Shoja, Mohammadali.

Handbook of Prostate Cancer Cell Research: Growth, Signalling, and Survival. Nova Science Publishers, Inc., 2009. p. 507-514.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ghabili, K, Agutter, PS & Mohajel Shoja, M 2009, Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer. in Handbook of Prostate Cancer Cell Research: Growth, Signalling, and Survival. Nova Science Publishers, Inc., pp. 507-514.
Ghabili K, Agutter PS, Mohajel Shoja M. Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer. In Handbook of Prostate Cancer Cell Research: Growth, Signalling, and Survival. Nova Science Publishers, Inc. 2009. p. 507-514
Ghabili, Kamyar ; Agutter, Paul S. ; Mohajel Shoja, Mohammadali. / Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer. Handbook of Prostate Cancer Cell Research: Growth, Signalling, and Survival. Nova Science Publishers, Inc., 2009. pp. 507-514
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