Abstract
Electromagnetic fields (EMF) may contribute to the pathogenesis of prostate cancer, but the mechanism is obscure. Numerous calcium/phosphorus crystalloids with various morphologies have been found in the normal prostate gland and in both benign and malignant prostate lesions. Their distribution within the gland is heterogeneous and diffuse. We propose that an environmental EMF may exert a piezoelectric effect on these crystalloids, resulting in simultaneous, multidirectional and diffuse compression or expansion and consequently a slight mechanical distortion of the prostate. Such distortion is known to alter gene expression in many kinds of cells and therefore cell phenotype; such alterations can suppress apoptosis. In this paper we explore the scientific and clinical evidence favoring this hypothesis and present a mathematical model of the proposed cell-mechanical effect.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Prostate Cancer Cell Research |
| Subtitle of host publication | Growth, Signalling, and Survival |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 507-514 |
| Number of pages | 8 |
| ISBN (Print) | 9781607419549 |
| State | Published - Dec 1 2009 |
| Externally published | Yes |
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Keywords
- Cell mechanics
- Crystalloid
- Electromagnetic field
- Piezoelectric effect
- Prostate cancer
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer. / Ghabili, Kamyar; Agutter, Paul S.; Mohajel Shoja, Mohammadali.
Handbook of Prostate Cancer Cell Research: Growth, Signalling, and Survival. Nova Science Publishers, Inc., 2009. p. 507-514.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic field and prostate cancer
AU - Ghabili, Kamyar
AU - Agutter, Paul S.
AU - Mohajel Shoja, Mohammadali
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Electromagnetic fields (EMF) may contribute to the pathogenesis of prostate cancer, but the mechanism is obscure. Numerous calcium/phosphorus crystalloids with various morphologies have been found in the normal prostate gland and in both benign and malignant prostate lesions. Their distribution within the gland is heterogeneous and diffuse. We propose that an environmental EMF may exert a piezoelectric effect on these crystalloids, resulting in simultaneous, multidirectional and diffuse compression or expansion and consequently a slight mechanical distortion of the prostate. Such distortion is known to alter gene expression in many kinds of cells and therefore cell phenotype; such alterations can suppress apoptosis. In this paper we explore the scientific and clinical evidence favoring this hypothesis and present a mathematical model of the proposed cell-mechanical effect.
AB - Electromagnetic fields (EMF) may contribute to the pathogenesis of prostate cancer, but the mechanism is obscure. Numerous calcium/phosphorus crystalloids with various morphologies have been found in the normal prostate gland and in both benign and malignant prostate lesions. Their distribution within the gland is heterogeneous and diffuse. We propose that an environmental EMF may exert a piezoelectric effect on these crystalloids, resulting in simultaneous, multidirectional and diffuse compression or expansion and consequently a slight mechanical distortion of the prostate. Such distortion is known to alter gene expression in many kinds of cells and therefore cell phenotype; such alterations can suppress apoptosis. In this paper we explore the scientific and clinical evidence favoring this hypothesis and present a mathematical model of the proposed cell-mechanical effect.
KW - Cell mechanics
KW - Crystalloid
KW - Electromagnetic field
KW - Piezoelectric effect
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84896209586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896209586&partnerID=8YFLogxK
M3 - Chapter
SN - 9781607419549
SP - 507
EP - 514
BT - Handbook of Prostate Cancer Cell Research
PB - Nova Science Publishers, Inc.
ER -