Piezoelectricity and prostate cancer: Proposed interaction between electromagnetic field and prostatic crystalloids

Kamyar Ghabili, Mohammadali Mohajel Shoja, Paul S. Agutter

Research output: Contribution to journalShort survey

5 Scopus citations

Abstract

There is evidence that electromagnetic fields (EMF) play some part in the pathogenesis of prostate cancer, but the pathogenic mechanism remains unknown. The normal prostate gland and both benign and malignant prostate lesions contain abundant calcium/phosphorus crystalloids with various morphologies, which seem to be heterogeneously and diffusely distributed within the gland. We hypothesize that an environmental EMF may result in simultaneous, multidirectional and diffuse compression or expansion of these crystalloids (a piezoelectric effect). This would result in a slight mechanical distortion of the prostate, potentially altering cell behavior and enhancing the expression of specific genes, particularly those involved in suppressing apoptosis. A mathematical model of the cell mechanical effect is presented, and the hypothesis is related to current clinical evidence and to potential validation by critical laboratory tests.

Original languageEnglish (US)
Pages (from-to)688-691
Number of pages4
JournalCell Biology International
Volume32
Issue number6
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Keywords

  • Cell mechanics
  • Crystalloid
  • Electromagnetic field
  • Piezoelectric effect
  • Prostate cancer

ASJC Scopus subject areas

  • Cell Biology

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