Some piperidine-based nocaine/modafinil hybrid ligands have been designed, synthesized, and found to display an improved potency at all three monoamine transporters and particularly for DAT and/or NET. Some highly active and selective monoamine transporter inhibitors with low nanomolar to subnanomolar potency were identified. Ligands of this type may find important applications as positron emission tomography imaging tools and in the treatment of central nervous system disorders such as depression and sleep apnea.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of medicinal chemistry|
|State||Published - Nov 18 2004|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery