Pitfalls and Misinterpretations of Cardiac Findings on PET/CT Imaging: A Careful Look at the Heart in Oncology Patients

Sonia L. Betancourt Cuellar; Diana Palacio; Marcelo F. Benveniste; Brett W. Carter; Gregory Gladish

doi:10.1067/j.cpradiol.2018.02.002

Pitfalls and Misinterpretations of Cardiac Findings on PET/CT Imaging: A Careful Look at the Heart in Oncology Patients

Sonia L. Betancourt Cuellar
, Diana Palacio
, Marcelo F. Benveniste
, Brett W. Carter
, Gregory Gladish

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Positron emission tomography (PET) computed tomography (CT) with 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG) has been established as an effective modality for evaluation of cancer. Interpretations of patterns of physiologic ¹⁸ F-FDG uptake by the heart is particularly difficult given the wide normal variations of ¹⁸ F-FDG metabolic activity observed. Atypical patterns of focal or diffuse physiologic cardiac ¹⁸ F-FDG uptake and post-therapeutic effects after radiation therapy, systemic diseases, or cardiomyopathy may also be confused with malignant disease on ¹⁸ F-FDG PET/CT. In this article, we review the variations of normal cardiac ¹⁸ F-FDG uptake observed in oncology patients and the appearances of other patterns of pathologic metabolic activity, related or not related to the malignancy being investigated, that may lead to false-negative and false-positive results.

Original language	English (US)
Pages (from-to)	172-183
Number of pages	12
Journal	Current Problems in Diagnostic Radiology
Volume	48
Issue number	2
DOIs	https://doi.org/10.1067/j.cpradiol.2018.02.002
State	Published - Mar 1 2019
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1067/j.cpradiol.2018.02.002

Cite this

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title = "Pitfalls and Misinterpretations of Cardiac Findings on PET/CT Imaging: A Careful Look at the Heart in Oncology Patients",

abstract = " Positron emission tomography (PET) computed tomography (CT) with 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG) has been established as an effective modality for evaluation of cancer. Interpretations of patterns of physiologic 18 F-FDG uptake by the heart is particularly difficult given the wide normal variations of 18 F-FDG metabolic activity observed. Atypical patterns of focal or diffuse physiologic cardiac 18 F-FDG uptake and post-therapeutic effects after radiation therapy, systemic diseases, or cardiomyopathy may also be confused with malignant disease on 18 F-FDG PET/CT. In this article, we review the variations of normal cardiac 18 F-FDG uptake observed in oncology patients and the appearances of other patterns of pathologic metabolic activity, related or not related to the malignancy being investigated, that may lead to false-negative and false-positive results.",

author = "\{Betancourt Cuellar\}, \{Sonia L.\} and Diana Palacio and Benveniste, \{Marcelo F.\} and Carter, \{Brett W.\} and Gregory Gladish",

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T2 - A Careful Look at the Heart in Oncology Patients

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AU - Benveniste, Marcelo F.

AU - Carter, Brett W.

AU - Gladish, Gregory

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Y1 - 2019/3/1

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AB - Positron emission tomography (PET) computed tomography (CT) with 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG) has been established as an effective modality for evaluation of cancer. Interpretations of patterns of physiologic 18 F-FDG uptake by the heart is particularly difficult given the wide normal variations of 18 F-FDG metabolic activity observed. Atypical patterns of focal or diffuse physiologic cardiac 18 F-FDG uptake and post-therapeutic effects after radiation therapy, systemic diseases, or cardiomyopathy may also be confused with malignant disease on 18 F-FDG PET/CT. In this article, we review the variations of normal cardiac 18 F-FDG uptake observed in oncology patients and the appearances of other patterns of pathologic metabolic activity, related or not related to the malignancy being investigated, that may lead to false-negative and false-positive results.

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Pitfalls and Misinterpretations of Cardiac Findings on PET/CT Imaging: A Careful Look at the Heart in Oncology Patients

Abstract

ASJC Scopus subject areas

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