Pituitary adenylate cyclase activating polypeptide stimulates release of peptide YY

T. Zhang, Guillermo Gomez, N. Yanaihara, T. Mochizuki, J. C. Thompson, G. H. Greeley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of these experiments was to examine the effects of the recently discovered gastrointestinal peptide, pituitary adenylate cyclase activating polypeptide (PACAP), and two structurally related peptides, vasoactive intestinal polypeptide and secretin, on release of peptide YY (PYY) in conscious dogs. Intravenous administration of PACAP-27 or -38 stimulated a dose-related release of PYY; PACAP-27 was more potent than PACAP-38. PACAP-stimulated release of PYY was inhibited significantly by atropine, whereas ganglionic or β-adrenergic blockade with hexamethonium and propranolol treatment, respectively, did not affect PACAP-induced release of PYY significantly (P > 0.05). These results indicate that PACAP-induced release of PYY is cholinergic dependent and that β-adrenergic tone and ganglionic transmission do not participate in PACAP-induced release of PYY. PACAP may play a role in the neural regulation of PYY release.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume264
Issue number6 27-6
StatePublished - 1993

Fingerprint

Peptide YY
Pituitary Adenylate Cyclase-Activating Polypeptide
Adrenergic Agents
Hexamethonium
Peptides
Secretin
Vasoactive Intestinal Peptide
Atropine
Propranolol
Intravenous Administration
Cholinergic Agents
Dogs

Keywords

  • colon
  • dog
  • endocrine
  • neural
  • vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

Zhang, T., Gomez, G., Yanaihara, N., Mochizuki, T., Thompson, J. C., & Greeley, G. H. (1993). Pituitary adenylate cyclase activating polypeptide stimulates release of peptide YY. American Journal of Physiology - Endocrinology and Metabolism, 264(6 27-6).

Pituitary adenylate cyclase activating polypeptide stimulates release of peptide YY. / Zhang, T.; Gomez, Guillermo; Yanaihara, N.; Mochizuki, T.; Thompson, J. C.; Greeley, G. H.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 264, No. 6 27-6, 1993.

Research output: Contribution to journalArticle

Zhang, T, Gomez, G, Yanaihara, N, Mochizuki, T, Thompson, JC & Greeley, GH 1993, 'Pituitary adenylate cyclase activating polypeptide stimulates release of peptide YY', American Journal of Physiology - Endocrinology and Metabolism, vol. 264, no. 6 27-6.
Zhang, T. ; Gomez, Guillermo ; Yanaihara, N. ; Mochizuki, T. ; Thompson, J. C. ; Greeley, G. H. / Pituitary adenylate cyclase activating polypeptide stimulates release of peptide YY. In: American Journal of Physiology - Endocrinology and Metabolism. 1993 ; Vol. 264, No. 6 27-6.
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