Pituitary dysfunction after traumatic brain injury

Screening and hormone replacement

Sreedevi Guttikonda, Sara Ahmadi, Randall Urban

Research output: Contribution to journalArticle

Abstract

This article highlights the risk of hypopituitarism in survivors of traumatic brain injury (TBI), an underdiagnosed clinical problem. Clinical evidence shows that anterior pituitary dysfunction is common in TBI survivors evaluated at least 6 months after the TBI, with an estimated prevalence of up to 27.5%. Although patients who suffer from moderate-to-severe TBI appear to be at higher risk, the emerging data suggest that mild-intensity trauma can also precede hypopituitarism. Since many of the symptoms of hypopituitarism are similar to those of TBI, it is important for clinicians to be aware of this clinical problem. Moreover, we will address questions such as when to screen and who should be screened, along with a discussion of current management of pituitary dysfunction in patients with TBI.

Original languageEnglish (US)
Pages (from-to)697-703
Number of pages7
JournalExpert Review of Endocrinology and Metabolism
Volume6
Issue number5
DOIs
StatePublished - Sep 2011

Fingerprint

Hormones
Hypopituitarism
Survivors
Traumatic Brain Injury
Wounds and Injuries

Keywords

  • growth hormone deficiency
  • hypopituitarism
  • pituitary hormone replacement
  • traumatic brain injury

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Pituitary dysfunction after traumatic brain injury : Screening and hormone replacement. / Guttikonda, Sreedevi; Ahmadi, Sara; Urban, Randall.

In: Expert Review of Endocrinology and Metabolism, Vol. 6, No. 5, 09.2011, p. 697-703.

Research output: Contribution to journalArticle

@article{3cbdfb513d9f454c92e805584683218f,
title = "Pituitary dysfunction after traumatic brain injury: Screening and hormone replacement",
abstract = "This article highlights the risk of hypopituitarism in survivors of traumatic brain injury (TBI), an underdiagnosed clinical problem. Clinical evidence shows that anterior pituitary dysfunction is common in TBI survivors evaluated at least 6 months after the TBI, with an estimated prevalence of up to 27.5{\%}. Although patients who suffer from moderate-to-severe TBI appear to be at higher risk, the emerging data suggest that mild-intensity trauma can also precede hypopituitarism. Since many of the symptoms of hypopituitarism are similar to those of TBI, it is important for clinicians to be aware of this clinical problem. Moreover, we will address questions such as when to screen and who should be screened, along with a discussion of current management of pituitary dysfunction in patients with TBI.",
keywords = "growth hormone deficiency, hypopituitarism, pituitary hormone replacement, traumatic brain injury",
author = "Sreedevi Guttikonda and Sara Ahmadi and Randall Urban",
year = "2011",
month = "9",
doi = "10.1586/eem.11.59",
language = "English (US)",
volume = "6",
pages = "697--703",
journal = "Expert Review of Endocrinology and Metabolism",
issn = "1744-6651",
publisher = "Expert Reviews Ltd.",
number = "5",

}

TY - JOUR

T1 - Pituitary dysfunction after traumatic brain injury

T2 - Screening and hormone replacement

AU - Guttikonda, Sreedevi

AU - Ahmadi, Sara

AU - Urban, Randall

PY - 2011/9

Y1 - 2011/9

N2 - This article highlights the risk of hypopituitarism in survivors of traumatic brain injury (TBI), an underdiagnosed clinical problem. Clinical evidence shows that anterior pituitary dysfunction is common in TBI survivors evaluated at least 6 months after the TBI, with an estimated prevalence of up to 27.5%. Although patients who suffer from moderate-to-severe TBI appear to be at higher risk, the emerging data suggest that mild-intensity trauma can also precede hypopituitarism. Since many of the symptoms of hypopituitarism are similar to those of TBI, it is important for clinicians to be aware of this clinical problem. Moreover, we will address questions such as when to screen and who should be screened, along with a discussion of current management of pituitary dysfunction in patients with TBI.

AB - This article highlights the risk of hypopituitarism in survivors of traumatic brain injury (TBI), an underdiagnosed clinical problem. Clinical evidence shows that anterior pituitary dysfunction is common in TBI survivors evaluated at least 6 months after the TBI, with an estimated prevalence of up to 27.5%. Although patients who suffer from moderate-to-severe TBI appear to be at higher risk, the emerging data suggest that mild-intensity trauma can also precede hypopituitarism. Since many of the symptoms of hypopituitarism are similar to those of TBI, it is important for clinicians to be aware of this clinical problem. Moreover, we will address questions such as when to screen and who should be screened, along with a discussion of current management of pituitary dysfunction in patients with TBI.

KW - growth hormone deficiency

KW - hypopituitarism

KW - pituitary hormone replacement

KW - traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=80052433523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052433523&partnerID=8YFLogxK

U2 - 10.1586/eem.11.59

DO - 10.1586/eem.11.59

M3 - Article

VL - 6

SP - 697

EP - 703

JO - Expert Review of Endocrinology and Metabolism

JF - Expert Review of Endocrinology and Metabolism

SN - 1744-6651

IS - 5

ER -