@article{dabdef5fe0034271ae2b14c6e462f8db,
title = "Pituitary function in adult males receiving medroxyprogesterone acetate",
abstract = "The pituitary, adrenal, and gonadal functions of nine males (six XY, two XYYm and one XY/XYY) were studied after at least 6 months of medroxyprogesterone acetate (MPA) therapy for antisocial or sex-offending behavior. Five were studied both before and during therapy, four only during therapy. MPA was effective in decreasing serum gonadotropin and plasma testosterone concentrations. MPA caused no change in the 24-hour rhythm or total integrated concentration of growth hormone. The plasma cortisol circadian rhythm was suppressed but not obliterated by MPA therapy. Although a significant decrease (P< 0.001) in 24-hour integrated concentrations of plasma cortisol was also found, the rise in the plasma cortisol level after insulin-induced hypoglycemia was unchanged.",
author = "Meyer, {W. J.} and Walker, {P. A.} and C. Wiedeking and J. Money and Kowarski, {A. A.} and Migeon, {C. J.} and Borgaonkar, {D. S.}",
note = "Funding Information: Received March 1, 1977; revised May 31, 1977; accepted June 3, 1977. *Supported by United States Public Health Service Grants AM-00180-23, HD-06284-05, 5K6-AM-21855 (to C. J. M.) and The Upjohn Company, Kalamazoo, Mich. The patients were studied in the Pediatric Clinical Research Unit, Department of Pediatrics, The Johns Hopkins Hospital, supported by Grant 5-M01-RR-0052 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health. tDepartment of Pediatrics. Present address: Gender Clinic, Departments of Pediatrics and Psychiatry, The University of Texas Medical Branch, Galveston, Tex. To whom reprint requests should be addressed at Division of Endocrinology, Department of Pediatrics, The University of Texas Medical Branch, Galveston, Tex. 77550. :j:Department of Psychiatry and Behavioral Sciences. Present address: Gender Clinic, Department of Psychiatry, The University of Texas Medical Branch, Galveston, Tex. §Departments of Pediatrics and Psychiatry and Behavioral Sciences. ~Department of Pediatrics. II Department of Medicine.",
year = "1977",
doi = "10.1016/s0015-0282(16)42857-8",
language = "English (US)",
volume = "28",
pages = "1072--1076",
journal = "Molecular Oncology",
issn = "1574-7891",
publisher = "Elsevier",
number = "10",
}