Pituitary function in adult males receiving medroxyprogesterone acetate

W. J. Meyer; P. A. Walker; C. Wiedeking; J. Money; A. A. Kowarski; C. J. Migeon; D. S. Borgaonkar

doi:10.1016/s0015-0282(16)42857-8

Pituitary function in adult males receiving medroxyprogesterone acetate

W. J. Meyer, P. A. Walker, C. Wiedeking, J. Money, A. A. Kowarski, C. J. Migeon, D. S. Borgaonkar

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The pituitary, adrenal, and gonadal functions of nine males (six XY, two XYYm and one XY/XYY) were studied after at least 6 months of medroxyprogesterone acetate (MPA) therapy for antisocial or sex-offending behavior. Five were studied both before and during therapy, four only during therapy. MPA was effective in decreasing serum gonadotropin and plasma testosterone concentrations. MPA caused no change in the 24-hour rhythm or total integrated concentration of growth hormone. The plasma cortisol circadian rhythm was suppressed but not obliterated by MPA therapy. Although a significant decrease (P< 0.001) in 24-hour integrated concentrations of plasma cortisol was also found, the rise in the plasma cortisol level after insulin-induced hypoglycemia was unchanged.

Original language	English (US)
Pages (from-to)	1072-1076
Number of pages	5
Journal	Unknown Journal
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/s0015-0282(16)42857-8
State	Published - 1977

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Pituitary function in adult males receiving medroxyprogesterone acetate",

abstract = "The pituitary, adrenal, and gonadal functions of nine males (six XY, two XYYm and one XY/XYY) were studied after at least 6 months of medroxyprogesterone acetate (MPA) therapy for antisocial or sex-offending behavior. Five were studied both before and during therapy, four only during therapy. MPA was effective in decreasing serum gonadotropin and plasma testosterone concentrations. MPA caused no change in the 24-hour rhythm or total integrated concentration of growth hormone. The plasma cortisol circadian rhythm was suppressed but not obliterated by MPA therapy. Although a significant decrease (P< 0.001) in 24-hour integrated concentrations of plasma cortisol was also found, the rise in the plasma cortisol level after insulin-induced hypoglycemia was unchanged.",

author = "Meyer, {W. J.} and Walker, {P. A.} and C. Wiedeking and J. Money and Kowarski, {A. A.} and Migeon, {C. J.} and Borgaonkar, {D. S.}",

year = "1977",

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language = "English (US)",

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T1 - Pituitary function in adult males receiving medroxyprogesterone acetate

AU - Meyer, W. J.

AU - Walker, P. A.

AU - Wiedeking, C.

AU - Money, J.

AU - Kowarski, A. A.

AU - Migeon, C. J.

AU - Borgaonkar, D. S.

PY - 1977

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