Abstract
The pituitary, adrenal, and gonadal functions of nine males (six XY, two XYYm and one XY/XYY) were studied after at least 6 months of medroxyprogesterone acetate (MPA) therapy for antisocial or sex-offending behavior. Five were studied both before and during therapy, four only during therapy. MPA was effective in decreasing serum gonadotropin and plasma testosterone concentrations. MPA caused no change in the 24-hour rhythm or total integrated concentration of growth hormone. The plasma cortisol circadian rhythm was suppressed but not obliterated by MPA therapy. Although a significant decrease (P< 0.001) in 24-hour integrated concentrations of plasma cortisol was also found, the rise in the plasma cortisol level after insulin-induced hypoglycemia was unchanged.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1072-1076 |
| Number of pages | 5 |
| Journal | Fertility and Sterility |
| Volume | 28 |
| Issue number | 10 |
| State | Published - 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Pituitary function in adult males receiving medroxyprogesterone acetate. / Meyer, Walter; Walker, P. A.; Wiedeking, C.; Money, J.; Kowarski, A. A.; Migeon, C. J.; Borgaonkar, D. S.
In: Fertility and Sterility, Vol. 28, No. 10, 1977, p. 1072-1076.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pituitary function in adult males receiving medroxyprogesterone acetate
AU - Meyer, Walter
AU - Walker, P. A.
AU - Wiedeking, C.
AU - Money, J.
AU - Kowarski, A. A.
AU - Migeon, C. J.
AU - Borgaonkar, D. S.
PY - 1977
Y1 - 1977
N2 - The pituitary, adrenal, and gonadal functions of nine males (six XY, two XYYm and one XY/XYY) were studied after at least 6 months of medroxyprogesterone acetate (MPA) therapy for antisocial or sex-offending behavior. Five were studied both before and during therapy, four only during therapy. MPA was effective in decreasing serum gonadotropin and plasma testosterone concentrations. MPA caused no change in the 24-hour rhythm or total integrated concentration of growth hormone. The plasma cortisol circadian rhythm was suppressed but not obliterated by MPA therapy. Although a significant decrease (P< 0.001) in 24-hour integrated concentrations of plasma cortisol was also found, the rise in the plasma cortisol level after insulin-induced hypoglycemia was unchanged.
AB - The pituitary, adrenal, and gonadal functions of nine males (six XY, two XYYm and one XY/XYY) were studied after at least 6 months of medroxyprogesterone acetate (MPA) therapy for antisocial or sex-offending behavior. Five were studied both before and during therapy, four only during therapy. MPA was effective in decreasing serum gonadotropin and plasma testosterone concentrations. MPA caused no change in the 24-hour rhythm or total integrated concentration of growth hormone. The plasma cortisol circadian rhythm was suppressed but not obliterated by MPA therapy. Although a significant decrease (P< 0.001) in 24-hour integrated concentrations of plasma cortisol was also found, the rise in the plasma cortisol level after insulin-induced hypoglycemia was unchanged.
UR - http://www.scopus.com/inward/record.url?scp=0017763135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017763135&partnerID=8YFLogxK
M3 - Article
VL - 28
SP - 1072
EP - 1076
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 10
ER -