Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Yihua Cai, Xiaoyan Shen, Chuanlin Ding, Chunjian Qi, Kejia Li, Xia Li, Venkatakrishna R. Jala, Huang ge Zhang, Tian Wang, Jie Zheng, Jun Yan

Research output: Contribution to journalArticle

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Abstract

Interleukin-23 (IL-23) and CD4 + T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal γδ T cells to produce IL-17 that led to disease progression. Dermal γδ T cells constitutively expressed the IL-23 receptor (IL-23R) and transcriptional factor RORγt. IL-17 production from dermal γδ T cells was independent of αβ T cells. The epidermal hyperplasia and inflammation induced by IL-23 were significantly decreased in T cell receptor δ-deficient (Tcrd -/-) and IL-17 receptor-deficient (Il17ra -/-) mice but occurred normally in Tcra -/- mice. Imiquimod-induced skin pathology was also significantly decreased in Tcrd -/- mice. Perhaps further promoting disease progression, IL-23 stimulated dermal γδ T cell expansion. In psoriasis patients, γδ T cells were greatly increased in affected skin and produced large amounts of IL-17. Thus, IL-23-responsive dermal γδ T cells are the major IL-17 producers in the skin and may represent a novel target for the treatment of psoriasis.

Original languageEnglish (US)
Pages (from-to)596-610
Number of pages15
JournalImmunity
Volume35
Issue number4
DOIs
StatePublished - Oct 28 2011

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Interleukin-17
Interleukin-23
Inflammation
T-Lymphocytes
Skin
Psoriasis
imiquimod
Disease Progression
Interleukin-17 Receptors
Interleukin Receptors
Th17 Cells
T-Cell Antigen Receptor
Hyperplasia
Pathology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X., ... Yan, J. (2011). Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation. Immunity, 35(4), 596-610. https://doi.org/10.1016/j.immuni.2011.08.001

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation. / Cai, Yihua; Shen, Xiaoyan; Ding, Chuanlin; Qi, Chunjian; Li, Kejia; Li, Xia; Jala, Venkatakrishna R.; Zhang, Huang ge; Wang, Tian; Zheng, Jie; Yan, Jun.

In: Immunity, Vol. 35, No. 4, 28.10.2011, p. 596-610.

Research output: Contribution to journalArticle

Cai, Y, Shen, X, Ding, C, Qi, C, Li, K, Li, X, Jala, VR, Zhang, HG, Wang, T, Zheng, J & Yan, J 2011, 'Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation', Immunity, vol. 35, no. 4, pp. 596-610. https://doi.org/10.1016/j.immuni.2011.08.001
Cai, Yihua ; Shen, Xiaoyan ; Ding, Chuanlin ; Qi, Chunjian ; Li, Kejia ; Li, Xia ; Jala, Venkatakrishna R. ; Zhang, Huang ge ; Wang, Tian ; Zheng, Jie ; Yan, Jun. / Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation. In: Immunity. 2011 ; Vol. 35, No. 4. pp. 596-610.
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