Placental control of drug delivery

Sanaalarab Al-Enazy, Shariq Ali, Norah Albekairi, Marwa El-Tawil, Erik Rytting

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream-whether from environmental contact, occupational exposure, medication, or drug abuse-the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.

Original languageEnglish (US)
JournalAdvanced Drug Delivery Reviews
DOIs
StateAccepted/In press - Jun 14 2016

Keywords

  • Biotransformation
  • Placenta
  • Pregnancy
  • Transporters

ASJC Scopus subject areas

  • Pharmaceutical Science

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