Placental control of drug delivery

Sanaalarab Al-Enazy, Shariq Ali, Norah Albekairi, Marwa El-Tawil, Erik Rytting

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume116
DOIs
StatePublished - Jul 1 2017

Keywords

  • Biotransformation
  • Placenta
  • Pregnancy
  • Transporters

ASJC Scopus subject areas

  • Pharmaceutical Science

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