TY - JOUR
T1 - Placental control of drug delivery
AU - Al-Enazy, Sanaalarab
AU - Ali, Shariq
AU - Albekairi, Norah
AU - El-Tawil, Marwa
AU - Rytting, Erik
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.
AB - The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.
KW - Biotransformation
KW - Placenta
KW - Pregnancy
KW - Transporters
UR - http://www.scopus.com/inward/record.url?scp=84994608138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994608138&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2016.08.002
DO - 10.1016/j.addr.2016.08.002
M3 - Review article
C2 - 27527665
AN - SCOPUS:84994608138
SN - 0169-409X
VL - 116
SP - 63
EP - 72
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -