Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection

Arnaud Chêne, Valérie Briand, Akanni Adededji Abdoul Ibitokou, Sébastien Dechavanne, Achille Massougbodji, Philippe Deloron, Adrian J F Luty, Benoît Gamain, Nadine Fievet

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Pregnancy-associated malaria (PAM) can lead to severe complications for both mother and baby. Certain placental cytokine/chemokine profiles have been shown to reflect poor pregnancy outcomes, including maternal anemia and low birth weight. In intervillous plasma samples from 400 Beninese women living in an area where Plasmodium falciparum is endemic, we quantified 16 cytokines/chemokines. We assessed their profiles in groups with PAM, with maternal anemia, with preterm births, or with a low birth weight for gestational age. Repeated ultrasound measurements ensured that prematurity and low birth weight were highly accurate. Preliminary analyses revealed trends for lower cytokine/chemokine concentrations in placental plasma associated both with babies with low birth weight for gestational age and with P. falciparum infection during pregnancy, while, as a function of the latter, the concentration of gamma interferon (IFN-γ)-inducible protein 10 (IP-10) was higher. Multivariate analyses showed that (i) higher placental plasma interleukin-10 (IL-10) levels were associated with P. falciparum infections and (ii) independently of P. falciparum infections, lower concentrations of both IFN-γ and IL-5 were associated with low birth weight for gestational age. Our data further strengthen the idea that IL-10 and IP-10 could be useful diagnostic markers of P. falciparum infection during pregnancy. The concentrations of cytokines/chemokines in placental plasma may represent previously unrecognized markers of poor fetal growth.

Original languageEnglish (US)
Pages (from-to)3783-3789
Number of pages7
JournalInfection and Immunity
Volume82
Issue number9
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Plasmodium falciparum
Pregnancy Outcome
Chemokines
Malaria
Low Birth Weight Infant
Cytokines
Gestational Age
Pregnancy
Mothers
Interleukin-10
Anemia
Chemokine CXCL10
Interleukin-5
Premature Birth
Fetal Development
Interferons
Interferon-gamma
Multivariate Analysis
Proteins

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Parasitology
  • Infectious Diseases

Cite this

Chêne, A., Briand, V., Ibitokou, A. A. A., Dechavanne, S., Massougbodji, A., Deloron, P., ... Fievet, N. (2014). Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection. Infection and Immunity, 82(9), 3783-3789. https://doi.org/10.1128/IAI.01922-14

Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection. / Chêne, Arnaud; Briand, Valérie; Ibitokou, Akanni Adededji Abdoul; Dechavanne, Sébastien; Massougbodji, Achille; Deloron, Philippe; Luty, Adrian J F; Gamain, Benoît; Fievet, Nadine.

In: Infection and Immunity, Vol. 82, No. 9, 2014, p. 3783-3789.

Research output: Contribution to journalArticle

Chêne, A, Briand, V, Ibitokou, AAA, Dechavanne, S, Massougbodji, A, Deloron, P, Luty, AJF, Gamain, B & Fievet, N 2014, 'Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection', Infection and Immunity, vol. 82, no. 9, pp. 3783-3789. https://doi.org/10.1128/IAI.01922-14
Chêne, Arnaud ; Briand, Valérie ; Ibitokou, Akanni Adededji Abdoul ; Dechavanne, Sébastien ; Massougbodji, Achille ; Deloron, Philippe ; Luty, Adrian J F ; Gamain, Benoît ; Fievet, Nadine. / Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection. In: Infection and Immunity. 2014 ; Vol. 82, No. 9. pp. 3783-3789.
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