Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis

Valérie Soulard, Martin Amadoudji Zin, Catherine Fitting, Akanni Adededji Abdoul Ibitokou, Mayke Oesterholt, Adrian J F Luty, René Xavier Perrin, Achille Massougbodji, Philippe Deloron, Antonio Bandeira, Nadine Fievet

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In areas where Plasmodium falciparum is endemic, pregnancy is associated with accumulation of infected red blood cells (RBCs) in the placenta, a condition referred to as placental malaria (PM). Infants born to PM-positive mothers are at an increased risk of malaria, which is putatively related to the transplacental passage of parasite-derived antigens, with consequent tolerization of the fetal immune system. Here we addressed the impact of PM on the regulation of neonatal T cell responses. We found that the frequency of regulatory CD25+ CD127-/low Foxp3+ CD4+ T cells was significantly decreased in neonates born to mothers with high levels of P. falciparum-induced placental inflammation, consisting mainly of primigravid mothers. However, at the individual level, the ratio between regulatory and effector (CD25+ CD127+ Foxp3-) CD4+ T cells was unaffected by PM. In addition, parasite-induced CD4+ T cell activation and production of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and IL-10 were strongly reduced in neonates born to PM-positive mothers. Thus, our results show that active PM at delivery is associated with a marked suppression of P. falciparum-specific cellular neonatal immune responses, affecting secretion of both pro- and antiinflammatory cytokines. Additionally, our results suggest that, as in adults, effector and regulatory CD4+ T cell populations are tightly coregulated in all neonates, irrespective of the maternal infection status.

Original languageEnglish (US)
Pages (from-to)2801-2809
Number of pages9
JournalInfection and Immunity
Volume79
Issue number7
DOIs
StatePublished - Jul 2011
Externally publishedYes

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Malaria
Parasites
Homeostasis
Newborn Infant
T-Lymphocytes
Mothers
Plasmodium falciparum
Regulatory T-Lymphocytes
Cellular Immunity
Interleukin-10
Placenta
Immune System
Interleukin-6
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Erythrocytes
Cytokines
Inflammation
Antigens
Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Parasitology
  • Infectious Diseases

Cite this

Soulard, V., Zin, M. A., Fitting, C., Ibitokou, A. A. A., Oesterholt, M., Luty, A. J. F., ... Fievet, N. (2011). Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis. Infection and Immunity, 79(7), 2801-2809. https://doi.org/10.1128/IAI.00203-11

Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis. / Soulard, Valérie; Zin, Martin Amadoudji; Fitting, Catherine; Ibitokou, Akanni Adededji Abdoul; Oesterholt, Mayke; Luty, Adrian J F; Perrin, René Xavier; Massougbodji, Achille; Deloron, Philippe; Bandeira, Antonio; Fievet, Nadine.

In: Infection and Immunity, Vol. 79, No. 7, 07.2011, p. 2801-2809.

Research output: Contribution to journalArticle

Soulard, V, Zin, MA, Fitting, C, Ibitokou, AAA, Oesterholt, M, Luty, AJF, Perrin, RX, Massougbodji, A, Deloron, P, Bandeira, A & Fievet, N 2011, 'Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis', Infection and Immunity, vol. 79, no. 7, pp. 2801-2809. https://doi.org/10.1128/IAI.00203-11
Soulard, Valérie ; Zin, Martin Amadoudji ; Fitting, Catherine ; Ibitokou, Akanni Adededji Abdoul ; Oesterholt, Mayke ; Luty, Adrian J F ; Perrin, René Xavier ; Massougbodji, Achille ; Deloron, Philippe ; Bandeira, Antonio ; Fievet, Nadine. / Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis. In: Infection and Immunity. 2011 ; Vol. 79, No. 7. pp. 2801-2809.
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