Plaque-medial rewelding with reversible tissue optical property changes during receptive cw Nd

YAG laser exposure

J. R. Spears, L. M. James, B. M. Leonard, I. N. Sinclair, R. D. Jenkins, Massoud Motamedi, E. L. Sinofsky

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Laser dosimetry for thermal fusion of plaque-wall separations during laser balloon angioplasty (LBA) is dependent upon the optical properties of the atheromatous arterial wall during one or more exposures to cw Nd:YAG laser radiation. An integrating sphere technique was used to measure relative transmission and reflection continuously during irradiation of human postmortem atheromatous aortic sections. Tissue luminal surface temperature was recorded continuously with a thermographic video imager during repetitive 20-30-sec, 8-15-watt exposure of a 3-mm nominal spot. In all specimens, transmission fell progressively during each exposure to 10-70% of baseline values. This effect was reversible with normalization of transmission during the initial phase of each subsequent exposure. Changes in transmission were inversely related to temperature over a 50-170°C range, whereas relative reflection remained constant. Accompanying reversible transmission changes was the observation that the weld strength of plaque-aortic wall separations was unchanged by repetitive laser welding and tissue separation of individual sections. In conclusion, temperature-dependent reversible optical and physical properties of plaque occur during exposure to 1.06 μm cw laser radiation.

Original languageEnglish (US)
Pages (from-to)477-485
Number of pages9
JournalLasers in Surgery and Medicine
Volume8
Issue number5
StatePublished - 1988
Externally publishedYes

Fingerprint

Solid-State Lasers
Lasers
Temperature
Laser-Assisted Balloon Angioplasty
Radiation
Welding
Hot Temperature

ASJC Scopus subject areas

  • Surgery

Cite this

Spears, J. R., James, L. M., Leonard, B. M., Sinclair, I. N., Jenkins, R. D., Motamedi, M., & Sinofsky, E. L. (1988). Plaque-medial rewelding with reversible tissue optical property changes during receptive cw Nd: YAG laser exposure. Lasers in Surgery and Medicine, 8(5), 477-485.

Plaque-medial rewelding with reversible tissue optical property changes during receptive cw Nd : YAG laser exposure. / Spears, J. R.; James, L. M.; Leonard, B. M.; Sinclair, I. N.; Jenkins, R. D.; Motamedi, Massoud; Sinofsky, E. L.

In: Lasers in Surgery and Medicine, Vol. 8, No. 5, 1988, p. 477-485.

Research output: Contribution to journalArticle

Spears, JR, James, LM, Leonard, BM, Sinclair, IN, Jenkins, RD, Motamedi, M & Sinofsky, EL 1988, 'Plaque-medial rewelding with reversible tissue optical property changes during receptive cw Nd: YAG laser exposure', Lasers in Surgery and Medicine, vol. 8, no. 5, pp. 477-485.
Spears, J. R. ; James, L. M. ; Leonard, B. M. ; Sinclair, I. N. ; Jenkins, R. D. ; Motamedi, Massoud ; Sinofsky, E. L. / Plaque-medial rewelding with reversible tissue optical property changes during receptive cw Nd : YAG laser exposure. In: Lasers in Surgery and Medicine. 1988 ; Vol. 8, No. 5. pp. 477-485.
@article{dee3eb358c36483aa97957c265a2e795,
title = "Plaque-medial rewelding with reversible tissue optical property changes during receptive cw Nd: YAG laser exposure",
abstract = "Laser dosimetry for thermal fusion of plaque-wall separations during laser balloon angioplasty (LBA) is dependent upon the optical properties of the atheromatous arterial wall during one or more exposures to cw Nd:YAG laser radiation. An integrating sphere technique was used to measure relative transmission and reflection continuously during irradiation of human postmortem atheromatous aortic sections. Tissue luminal surface temperature was recorded continuously with a thermographic video imager during repetitive 20-30-sec, 8-15-watt exposure of a 3-mm nominal spot. In all specimens, transmission fell progressively during each exposure to 10-70{\%} of baseline values. This effect was reversible with normalization of transmission during the initial phase of each subsequent exposure. Changes in transmission were inversely related to temperature over a 50-170°C range, whereas relative reflection remained constant. Accompanying reversible transmission changes was the observation that the weld strength of plaque-aortic wall separations was unchanged by repetitive laser welding and tissue separation of individual sections. In conclusion, temperature-dependent reversible optical and physical properties of plaque occur during exposure to 1.06 μm cw laser radiation.",
author = "Spears, {J. R.} and James, {L. M.} and Leonard, {B. M.} and Sinclair, {I. N.} and Jenkins, {R. D.} and Massoud Motamedi and Sinofsky, {E. L.}",
year = "1988",
language = "English (US)",
volume = "8",
pages = "477--485",
journal = "Lasers in Surgery and Medicine",
issn = "0196-8092",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Plaque-medial rewelding with reversible tissue optical property changes during receptive cw Nd

T2 - YAG laser exposure

AU - Spears, J. R.

AU - James, L. M.

AU - Leonard, B. M.

AU - Sinclair, I. N.

AU - Jenkins, R. D.

AU - Motamedi, Massoud

AU - Sinofsky, E. L.

PY - 1988

Y1 - 1988

N2 - Laser dosimetry for thermal fusion of plaque-wall separations during laser balloon angioplasty (LBA) is dependent upon the optical properties of the atheromatous arterial wall during one or more exposures to cw Nd:YAG laser radiation. An integrating sphere technique was used to measure relative transmission and reflection continuously during irradiation of human postmortem atheromatous aortic sections. Tissue luminal surface temperature was recorded continuously with a thermographic video imager during repetitive 20-30-sec, 8-15-watt exposure of a 3-mm nominal spot. In all specimens, transmission fell progressively during each exposure to 10-70% of baseline values. This effect was reversible with normalization of transmission during the initial phase of each subsequent exposure. Changes in transmission were inversely related to temperature over a 50-170°C range, whereas relative reflection remained constant. Accompanying reversible transmission changes was the observation that the weld strength of plaque-aortic wall separations was unchanged by repetitive laser welding and tissue separation of individual sections. In conclusion, temperature-dependent reversible optical and physical properties of plaque occur during exposure to 1.06 μm cw laser radiation.

AB - Laser dosimetry for thermal fusion of plaque-wall separations during laser balloon angioplasty (LBA) is dependent upon the optical properties of the atheromatous arterial wall during one or more exposures to cw Nd:YAG laser radiation. An integrating sphere technique was used to measure relative transmission and reflection continuously during irradiation of human postmortem atheromatous aortic sections. Tissue luminal surface temperature was recorded continuously with a thermographic video imager during repetitive 20-30-sec, 8-15-watt exposure of a 3-mm nominal spot. In all specimens, transmission fell progressively during each exposure to 10-70% of baseline values. This effect was reversible with normalization of transmission during the initial phase of each subsequent exposure. Changes in transmission were inversely related to temperature over a 50-170°C range, whereas relative reflection remained constant. Accompanying reversible transmission changes was the observation that the weld strength of plaque-aortic wall separations was unchanged by repetitive laser welding and tissue separation of individual sections. In conclusion, temperature-dependent reversible optical and physical properties of plaque occur during exposure to 1.06 μm cw laser radiation.

UR - http://www.scopus.com/inward/record.url?scp=0023823821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023823821&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 477

EP - 485

JO - Lasers in Surgery and Medicine

JF - Lasers in Surgery and Medicine

SN - 0196-8092

IS - 5

ER -