Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension

D. C. Kem, M. H. Weinberger, J. R. Higgins, N. J. Kramer, C. Gomez-Sanchez, O. B. Holland

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

ACTHα(1-24) was infused at incremental rates of 12.5-200 ml mIU/30 min in dexamethasone-suppressed hypertensive patients on a regular sodium diet. The plasma aldosterone response to this stimulus in 8 patients with hyperaldosteronism due to an adrenal adenoma and 11 with adrenal hyperplasia was significantly greater at all infusion rates (P<0.05) when compared with the response in 6 normal subjects on a similar diet. This responsiveness to ACTH in the patients with primary hyperaldosteronism was similar to that of the normal subjects on a low sodium diet. Twelve patients with low renin and 6 patients with normal renin essential hypertension were similarly studied. There was no significant difference in the median aldosterone response between these 2 groups and the normal subjects on a normal diet, but the response was significantly lower compared with that in patients with primary hyperaldosteronism. These data show that patients with hyperaldosteronism from an adrenal adenoma or hyperplasia have a consistent and exaggerated response to ACTH. The hyper-responsiveness is not apparently shared by the majority of patients with low renin essential hypertension and does not support the concept that this group is an intermediate form of primary aldosteronism. Individual patients within this group, however, may have such a response and might be identified by this type of testing.

Original languageEnglish (US)
Pages (from-to)552-560
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume46
Issue number4
StatePublished - 1978

Fingerprint

Hyperaldosteronism
Nutrition
Aldosterone
Renin
Adrenocorticotropic Hormone
Hypertension
Plasmas
Sodium
Cosyntropin
Dexamethasone
Diet
Adenoma
Hyperplasia
Sodium-Restricted Diet
Testing

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Kem, D. C., Weinberger, M. H., Higgins, J. R., Kramer, N. J., Gomez-Sanchez, C., & Holland, O. B. (1978). Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. Journal of Clinical Endocrinology and Metabolism, 46(4), 552-560.

Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. / Kem, D. C.; Weinberger, M. H.; Higgins, J. R.; Kramer, N. J.; Gomez-Sanchez, C.; Holland, O. B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 46, No. 4, 1978, p. 552-560.

Research output: Contribution to journalArticle

Kem, DC, Weinberger, MH, Higgins, JR, Kramer, NJ, Gomez-Sanchez, C & Holland, OB 1978, 'Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension', Journal of Clinical Endocrinology and Metabolism, vol. 46, no. 4, pp. 552-560.
Kem, D. C. ; Weinberger, M. H. ; Higgins, J. R. ; Kramer, N. J. ; Gomez-Sanchez, C. ; Holland, O. B. / Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. In: Journal of Clinical Endocrinology and Metabolism. 1978 ; Vol. 46, No. 4. pp. 552-560.
@article{7ad065682f7b4f58bf1fc2c97f2b9b9c,
title = "Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension",
abstract = "ACTHα(1-24) was infused at incremental rates of 12.5-200 ml mIU/30 min in dexamethasone-suppressed hypertensive patients on a regular sodium diet. The plasma aldosterone response to this stimulus in 8 patients with hyperaldosteronism due to an adrenal adenoma and 11 with adrenal hyperplasia was significantly greater at all infusion rates (P<0.05) when compared with the response in 6 normal subjects on a similar diet. This responsiveness to ACTH in the patients with primary hyperaldosteronism was similar to that of the normal subjects on a low sodium diet. Twelve patients with low renin and 6 patients with normal renin essential hypertension were similarly studied. There was no significant difference in the median aldosterone response between these 2 groups and the normal subjects on a normal diet, but the response was significantly lower compared with that in patients with primary hyperaldosteronism. These data show that patients with hyperaldosteronism from an adrenal adenoma or hyperplasia have a consistent and exaggerated response to ACTH. The hyper-responsiveness is not apparently shared by the majority of patients with low renin essential hypertension and does not support the concept that this group is an intermediate form of primary aldosteronism. Individual patients within this group, however, may have such a response and might be identified by this type of testing.",
author = "Kem, {D. C.} and Weinberger, {M. H.} and Higgins, {J. R.} and Kramer, {N. J.} and C. Gomez-Sanchez and Holland, {O. B.}",
year = "1978",
language = "English (US)",
volume = "46",
pages = "552--560",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "4",

}

TY - JOUR

T1 - Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension

AU - Kem, D. C.

AU - Weinberger, M. H.

AU - Higgins, J. R.

AU - Kramer, N. J.

AU - Gomez-Sanchez, C.

AU - Holland, O. B.

PY - 1978

Y1 - 1978

N2 - ACTHα(1-24) was infused at incremental rates of 12.5-200 ml mIU/30 min in dexamethasone-suppressed hypertensive patients on a regular sodium diet. The plasma aldosterone response to this stimulus in 8 patients with hyperaldosteronism due to an adrenal adenoma and 11 with adrenal hyperplasia was significantly greater at all infusion rates (P<0.05) when compared with the response in 6 normal subjects on a similar diet. This responsiveness to ACTH in the patients with primary hyperaldosteronism was similar to that of the normal subjects on a low sodium diet. Twelve patients with low renin and 6 patients with normal renin essential hypertension were similarly studied. There was no significant difference in the median aldosterone response between these 2 groups and the normal subjects on a normal diet, but the response was significantly lower compared with that in patients with primary hyperaldosteronism. These data show that patients with hyperaldosteronism from an adrenal adenoma or hyperplasia have a consistent and exaggerated response to ACTH. The hyper-responsiveness is not apparently shared by the majority of patients with low renin essential hypertension and does not support the concept that this group is an intermediate form of primary aldosteronism. Individual patients within this group, however, may have such a response and might be identified by this type of testing.

AB - ACTHα(1-24) was infused at incremental rates of 12.5-200 ml mIU/30 min in dexamethasone-suppressed hypertensive patients on a regular sodium diet. The plasma aldosterone response to this stimulus in 8 patients with hyperaldosteronism due to an adrenal adenoma and 11 with adrenal hyperplasia was significantly greater at all infusion rates (P<0.05) when compared with the response in 6 normal subjects on a similar diet. This responsiveness to ACTH in the patients with primary hyperaldosteronism was similar to that of the normal subjects on a low sodium diet. Twelve patients with low renin and 6 patients with normal renin essential hypertension were similarly studied. There was no significant difference in the median aldosterone response between these 2 groups and the normal subjects on a normal diet, but the response was significantly lower compared with that in patients with primary hyperaldosteronism. These data show that patients with hyperaldosteronism from an adrenal adenoma or hyperplasia have a consistent and exaggerated response to ACTH. The hyper-responsiveness is not apparently shared by the majority of patients with low renin essential hypertension and does not support the concept that this group is an intermediate form of primary aldosteronism. Individual patients within this group, however, may have such a response and might be identified by this type of testing.

UR - http://www.scopus.com/inward/record.url?scp=0018090488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018090488&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 552

EP - 560

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -