Abstract
ACTHα(1-24) was infused at incremental rates of 12.5-200 ml mIU/30 min in dexamethasone-suppressed hypertensive patients on a regular sodium diet. The plasma aldosterone response to this stimulus in 8 patients with hyperaldosteronism due to an adrenal adenoma and 11 with adrenal hyperplasia was significantly greater at all infusion rates (P<0.05) when compared with the response in 6 normal subjects on a similar diet. This responsiveness to ACTH in the patients with primary hyperaldosteronism was similar to that of the normal subjects on a low sodium diet. Twelve patients with low renin and 6 patients with normal renin essential hypertension were similarly studied. There was no significant difference in the median aldosterone response between these 2 groups and the normal subjects on a normal diet, but the response was significantly lower compared with that in patients with primary hyperaldosteronism. These data show that patients with hyperaldosteronism from an adrenal adenoma or hyperplasia have a consistent and exaggerated response to ACTH. The hyper-responsiveness is not apparently shared by the majority of patients with low renin essential hypertension and does not support the concept that this group is an intermediate form of primary aldosteronism. Individual patients within this group, however, may have such a response and might be identified by this type of testing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 552-560 |
| Number of pages | 9 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 46 |
| Issue number | 4 |
| State | Published - 1978 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. / Kem, D. C.; Weinberger, M. H.; Higgins, J. R.; Kramer, N. J.; Gomez-Sanchez, C.; Holland, O. B.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 46, No. 4, 1978, p. 552-560.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension
AU - Kem, D. C.
AU - Weinberger, M. H.
AU - Higgins, J. R.
AU - Kramer, N. J.
AU - Gomez-Sanchez, C.
AU - Holland, O. B.
PY - 1978
Y1 - 1978
N2 - ACTHα(1-24) was infused at incremental rates of 12.5-200 ml mIU/30 min in dexamethasone-suppressed hypertensive patients on a regular sodium diet. The plasma aldosterone response to this stimulus in 8 patients with hyperaldosteronism due to an adrenal adenoma and 11 with adrenal hyperplasia was significantly greater at all infusion rates (P<0.05) when compared with the response in 6 normal subjects on a similar diet. This responsiveness to ACTH in the patients with primary hyperaldosteronism was similar to that of the normal subjects on a low sodium diet. Twelve patients with low renin and 6 patients with normal renin essential hypertension were similarly studied. There was no significant difference in the median aldosterone response between these 2 groups and the normal subjects on a normal diet, but the response was significantly lower compared with that in patients with primary hyperaldosteronism. These data show that patients with hyperaldosteronism from an adrenal adenoma or hyperplasia have a consistent and exaggerated response to ACTH. The hyper-responsiveness is not apparently shared by the majority of patients with low renin essential hypertension and does not support the concept that this group is an intermediate form of primary aldosteronism. Individual patients within this group, however, may have such a response and might be identified by this type of testing.
AB - ACTHα(1-24) was infused at incremental rates of 12.5-200 ml mIU/30 min in dexamethasone-suppressed hypertensive patients on a regular sodium diet. The plasma aldosterone response to this stimulus in 8 patients with hyperaldosteronism due to an adrenal adenoma and 11 with adrenal hyperplasia was significantly greater at all infusion rates (P<0.05) when compared with the response in 6 normal subjects on a similar diet. This responsiveness to ACTH in the patients with primary hyperaldosteronism was similar to that of the normal subjects on a low sodium diet. Twelve patients with low renin and 6 patients with normal renin essential hypertension were similarly studied. There was no significant difference in the median aldosterone response between these 2 groups and the normal subjects on a normal diet, but the response was significantly lower compared with that in patients with primary hyperaldosteronism. These data show that patients with hyperaldosteronism from an adrenal adenoma or hyperplasia have a consistent and exaggerated response to ACTH. The hyper-responsiveness is not apparently shared by the majority of patients with low renin essential hypertension and does not support the concept that this group is an intermediate form of primary aldosteronism. Individual patients within this group, however, may have such a response and might be identified by this type of testing.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018090488&partnerID=8YFLogxK
M3 - Article
VL - 46
SP - 552
EP - 560
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -