Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration

Milam A. Brantley, Melissa P. Osborn, Barton J. Sanders, Kasra A. Rezaei, Pengcheng Lu, Chun Li, Ginger L. Milne, Jiyang Cai, Paul Sternberg

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

• Purpose: To compare plasma levels of oxidative stress biomarkers in patients with age-related macular degeneration (AMD) and controls and to evaluate a potential relationship between biochemical markers of oxidative stress and AMD susceptibility genotypes. • Design: Prospective case-control study. • Methods: Plasma levels of oxidative stress biomarkers were determined in 77 AMD patients and 75 controls recruited from a clinical practice. Cysteine, cystine (CySS), glutathione, isoprostane, and isofuran were measured, and participants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes. • Results: CySS was elevated in cases compared with controls (P =.013). After adjustment for age, sex, and smoking, this association was not significant. In all participants, CySS levels were associated with the CFH polymorphism rs3753394 (P =.028) as well as an 8-allele CFH haplotype (P =.029) after correction for age, gender, and smoking. None of the other plasma markers was related to AMD status in our cohort. • Conclusions: Our investigation of the geneenvironment interaction involved in AMD revealed a relationship between a plasma biomarker of oxidative stress, CySS, and CFH genotype. These data suggest a potential association between inflammatory regulators and redox status in AMD pathogenesis.

Original languageEnglish (US)
Pages (from-to)460-467.e1
JournalAmerican Journal of Ophthalmology
Volume153
Issue number3
DOIs
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Ophthalmology

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    Brantley, M. A., Osborn, M. P., Sanders, B. J., Rezaei, K. A., Lu, P., Li, C., Milne, G. L., Cai, J., & Sternberg, P. (2012). Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. American Journal of Ophthalmology, 153(3), 460-467.e1. https://doi.org/10.1016/j.ajo.2011.08.033