Plasma creatine kinase B correlates with injury severity and symptoms in professional boxers

Joseph Kilianski, Sophie Peeters, Jeff Debad, Joseph Mohmed, Steven Wolf, Joseph P. Minei, Ramon Diaz-Arrastia, Joshua W. Gatson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Each year in the United States, approximately 1.7 million people sustain a traumatic brain injury (TBI). Of these TBI events, about 75 percent are characterized as being mild brain injuries. Immediately following TBI, a secondary brain damage persists for hours, days, and even months. Previously, detection of neuronal and glial biomarkers have proven to be useful to predict neurological outcomes. Here, we hypothesized that creatine kinase, brain (CKBB) is a sensitive biomarker for acute secondary brain injury in professional boxers. Methods: Blood (8 cc) was collected from the boxing athletes (n = 18) prior to and after competition (∼30 min). The plasma levels of CKBB were measured using the Meso Scale Diagnostic (MSD) electrochemiluminescence (ECL) array-based multiplex format. Additional data such as number of blows to the head and symptom score (Rivermead Post Concussion Symptoms Questionnaire) were collected. Results: At approximately 30 min after the competition, the plasma levels of CKBB were significantly elevated in concussed professional boxers and correlated with the number of blows to the head and symptom scores. Additionally, receiver operating curve (ROC) analysis yielded a 77.8% sensitivity and a specificity of 82.4% with an area under the curve (AUC) of 90% for CKBB as an identifier of secondary brain injury within this population. Conclusion: This study describes the detection of CKBB as a brain biomarker to detect secondary brain injury in professional athletes that have experienced multiple high impact blows to the head. This acute biomarker may prove useful in monitoring secondary brain injury after injury.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalJournal of Clinical Neuroscience
Volume45
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Fingerprint

Creatine Kinase
Brain Injuries
Biomarkers
Wounds and Injuries
Head
Athletes
Post-Concussion Syndrome
BB Form Creatine Kinase
Boxing
Brain
Neuroglia
Area Under Curve
Sensitivity and Specificity
Population
Traumatic Brain Injury

Keywords

  • CKBB
  • Concussion
  • Mild TBI

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Plasma creatine kinase B correlates with injury severity and symptoms in professional boxers. / Kilianski, Joseph; Peeters, Sophie; Debad, Jeff; Mohmed, Joseph; Wolf, Steven; Minei, Joseph P.; Diaz-Arrastia, Ramon; Gatson, Joshua W.

In: Journal of Clinical Neuroscience, Vol. 45, 01.11.2017, p. 100-104.

Research output: Contribution to journalArticle

Kilianski, J, Peeters, S, Debad, J, Mohmed, J, Wolf, S, Minei, JP, Diaz-Arrastia, R & Gatson, JW 2017, 'Plasma creatine kinase B correlates with injury severity and symptoms in professional boxers', Journal of Clinical Neuroscience, vol. 45, pp. 100-104. https://doi.org/10.1016/j.jocn.2017.07.021
Kilianski, Joseph ; Peeters, Sophie ; Debad, Jeff ; Mohmed, Joseph ; Wolf, Steven ; Minei, Joseph P. ; Diaz-Arrastia, Ramon ; Gatson, Joshua W. / Plasma creatine kinase B correlates with injury severity and symptoms in professional boxers. In: Journal of Clinical Neuroscience. 2017 ; Vol. 45. pp. 100-104.
@article{110dea91a60d4cd6b6fee424bd3a3a37,
title = "Plasma creatine kinase B correlates with injury severity and symptoms in professional boxers",
abstract = "Introduction: Each year in the United States, approximately 1.7 million people sustain a traumatic brain injury (TBI). Of these TBI events, about 75 percent are characterized as being mild brain injuries. Immediately following TBI, a secondary brain damage persists for hours, days, and even months. Previously, detection of neuronal and glial biomarkers have proven to be useful to predict neurological outcomes. Here, we hypothesized that creatine kinase, brain (CKBB) is a sensitive biomarker for acute secondary brain injury in professional boxers. Methods: Blood (8 cc) was collected from the boxing athletes (n = 18) prior to and after competition (∼30 min). The plasma levels of CKBB were measured using the Meso Scale Diagnostic (MSD) electrochemiluminescence (ECL) array-based multiplex format. Additional data such as number of blows to the head and symptom score (Rivermead Post Concussion Symptoms Questionnaire) were collected. Results: At approximately 30 min after the competition, the plasma levels of CKBB were significantly elevated in concussed professional boxers and correlated with the number of blows to the head and symptom scores. Additionally, receiver operating curve (ROC) analysis yielded a 77.8{\%} sensitivity and a specificity of 82.4{\%} with an area under the curve (AUC) of 90{\%} for CKBB as an identifier of secondary brain injury within this population. Conclusion: This study describes the detection of CKBB as a brain biomarker to detect secondary brain injury in professional athletes that have experienced multiple high impact blows to the head. This acute biomarker may prove useful in monitoring secondary brain injury after injury.",
keywords = "CKBB, Concussion, Mild TBI",
author = "Joseph Kilianski and Sophie Peeters and Jeff Debad and Joseph Mohmed and Steven Wolf and Minei, {Joseph P.} and Ramon Diaz-Arrastia and Gatson, {Joshua W.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.jocn.2017.07.021",
language = "English (US)",
volume = "45",
pages = "100--104",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Plasma creatine kinase B correlates with injury severity and symptoms in professional boxers

AU - Kilianski, Joseph

AU - Peeters, Sophie

AU - Debad, Jeff

AU - Mohmed, Joseph

AU - Wolf, Steven

AU - Minei, Joseph P.

AU - Diaz-Arrastia, Ramon

AU - Gatson, Joshua W.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Introduction: Each year in the United States, approximately 1.7 million people sustain a traumatic brain injury (TBI). Of these TBI events, about 75 percent are characterized as being mild brain injuries. Immediately following TBI, a secondary brain damage persists for hours, days, and even months. Previously, detection of neuronal and glial biomarkers have proven to be useful to predict neurological outcomes. Here, we hypothesized that creatine kinase, brain (CKBB) is a sensitive biomarker for acute secondary brain injury in professional boxers. Methods: Blood (8 cc) was collected from the boxing athletes (n = 18) prior to and after competition (∼30 min). The plasma levels of CKBB were measured using the Meso Scale Diagnostic (MSD) electrochemiluminescence (ECL) array-based multiplex format. Additional data such as number of blows to the head and symptom score (Rivermead Post Concussion Symptoms Questionnaire) were collected. Results: At approximately 30 min after the competition, the plasma levels of CKBB were significantly elevated in concussed professional boxers and correlated with the number of blows to the head and symptom scores. Additionally, receiver operating curve (ROC) analysis yielded a 77.8% sensitivity and a specificity of 82.4% with an area under the curve (AUC) of 90% for CKBB as an identifier of secondary brain injury within this population. Conclusion: This study describes the detection of CKBB as a brain biomarker to detect secondary brain injury in professional athletes that have experienced multiple high impact blows to the head. This acute biomarker may prove useful in monitoring secondary brain injury after injury.

AB - Introduction: Each year in the United States, approximately 1.7 million people sustain a traumatic brain injury (TBI). Of these TBI events, about 75 percent are characterized as being mild brain injuries. Immediately following TBI, a secondary brain damage persists for hours, days, and even months. Previously, detection of neuronal and glial biomarkers have proven to be useful to predict neurological outcomes. Here, we hypothesized that creatine kinase, brain (CKBB) is a sensitive biomarker for acute secondary brain injury in professional boxers. Methods: Blood (8 cc) was collected from the boxing athletes (n = 18) prior to and after competition (∼30 min). The plasma levels of CKBB were measured using the Meso Scale Diagnostic (MSD) electrochemiluminescence (ECL) array-based multiplex format. Additional data such as number of blows to the head and symptom score (Rivermead Post Concussion Symptoms Questionnaire) were collected. Results: At approximately 30 min after the competition, the plasma levels of CKBB were significantly elevated in concussed professional boxers and correlated with the number of blows to the head and symptom scores. Additionally, receiver operating curve (ROC) analysis yielded a 77.8% sensitivity and a specificity of 82.4% with an area under the curve (AUC) of 90% for CKBB as an identifier of secondary brain injury within this population. Conclusion: This study describes the detection of CKBB as a brain biomarker to detect secondary brain injury in professional athletes that have experienced multiple high impact blows to the head. This acute biomarker may prove useful in monitoring secondary brain injury after injury.

KW - CKBB

KW - Concussion

KW - Mild TBI

UR - http://www.scopus.com/inward/record.url?scp=85026846445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026846445&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2017.07.021

DO - 10.1016/j.jocn.2017.07.021

M3 - Article

VL - 45

SP - 100

EP - 104

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

ER -