Plasma cyst(e)ine in homocyst(e)inemia

M. H. Malloy, D. K. Rassin, G. E. Gaull

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Using a method developed to measure plasma protein-bound 1/2-cystine, we have observed that the metabolic state can affect the distribution of plasma cyst(e)ine between the bound and the free form. In five patients with homocyst(e)inemia, 1/2-homocystine was found to have replaced virtually all the cysteine normally present on sulfhydryl-binding sites of plasma proteins. The majority of the cyst(e)ine measured in the plasma of these patients (6.9 ± 2.4 μmol/dl, x̄ ±SD) was present in the form of a mixed disulfide with 1/2-homocystine (5.4 ± 0.9 μmol/dl) rather than being free in the plasma or bound to plasma proteins.

Original languageEnglish (US)
Pages (from-to)2619-2621
Number of pages3
JournalAmerican Journal of Clinical Nutrition
Issue number12
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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