Plasma cyst(e)ine in homocyst(e)inemia

Michael Malloy, D. K. Rassin, G. E. Gaull

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Using a method developed to measure plasma protein-bound 1/2-cystine, we have observed that the metabolic state can affect the distribution of plasma cyst(e)ine between the bound and the free form. In five patients with homocyst(e)inemia, 1/2-homocystine was found to have replaced virtually all the cysteine normally present on sulfhydryl-binding sites of plasma proteins. The majority of the cyst(e)ine measured in the plasma of these patients (6.9 ± 2.4 μmol/dl, x̄ ±SD) was present in the form of a mixed disulfide with 1/2-homocystine (5.4 ± 0.9 μmol/dl) rather than being free in the plasma or bound to plasma proteins.

Original languageEnglish (US)
Pages (from-to)2619-2621
Number of pages3
JournalAmerican Journal of Clinical Nutrition
Volume34
Issue number12
StatePublished - 1981
Externally publishedYes

Fingerprint

Homocystine
blood proteins
Cysts
Blood Proteins
homocysteine
Cystine
cystine
sulfides
Disulfides
Cysteine
cysteine
binding sites
Binding Sites
methodology

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Malloy, M., Rassin, D. K., & Gaull, G. E. (1981). Plasma cyst(e)ine in homocyst(e)inemia. American Journal of Clinical Nutrition, 34(12), 2619-2621.

Plasma cyst(e)ine in homocyst(e)inemia. / Malloy, Michael; Rassin, D. K.; Gaull, G. E.

In: American Journal of Clinical Nutrition, Vol. 34, No. 12, 1981, p. 2619-2621.

Research output: Contribution to journalArticle

Malloy, M, Rassin, DK & Gaull, GE 1981, 'Plasma cyst(e)ine in homocyst(e)inemia', American Journal of Clinical Nutrition, vol. 34, no. 12, pp. 2619-2621.
Malloy, Michael ; Rassin, D. K. ; Gaull, G. E. / Plasma cyst(e)ine in homocyst(e)inemia. In: American Journal of Clinical Nutrition. 1981 ; Vol. 34, No. 12. pp. 2619-2621.
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