Plasma cytokines during acute human fascioliasis

Catalina Aron-Said, Martin Montes, A. Clinton White, Miguel M. Cabada

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Fascioliasis is a foodborne trematode endemic worldwide. Children under 15 years have the highest prevalence of infection. We hypothesized that acute fascioliasis would be associated with more pronounced cytokine changes than in chronic disease or no helminth infections. To test this hypothesis, 33 children who lived in the Peruvian highlands were classified into 3 groups: acute fascioliasis, chronic fascioliasis, and no helminth infection. Type Th1, Th2, and Th17 cytokines were measured in plasma by cytometric bead array. Children with acute infection had higher levels of IL-5 and IL-17 compared with controls (p < 0.001 and p < 0.007, respectively). The increased IL-5 plasma concentration in children with acute infection was associated with the eosinophilia found in that group.

Original languageEnglish (US)
Pages (from-to)2965-2968
Number of pages4
JournalParasitology research
Issue number8
StatePublished - Aug 2021


  • Fasciola
  • IL-17
  • IL-5

ASJC Scopus subject areas

  • Parasitology
  • General Veterinary
  • Insect Science
  • Infectious Diseases


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