Plasma epinephrine, norepinephrine, and cortisol of multigravidas in pregnancy and labor and in umbilical cord arteries after delivery

R. P. Lederman, E. Lederman, B. A. Work, D. S. McCann

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Plasma epinephrine, norepinephrine and cortisol levels were determined for 61 full-term multigravidas in last trimester pregnancy and during three phases of labor: 3-4 cm (Phase 1), 7 cm (Phase 2), and 10 cm (Phase 3) cervical dilatation. Maternal venous and cord arterial samples were obtained after delivery (Phase 4). Epinephrine shows significant increases in the mean and variance from pregnancy through Phases 1-3 of labor. Cortisol levels rise significantly in every phase of labor. Norepinephrine levels increase significantly only after delivery. Multigravidas, compared to primigravidas, had significantly higher prenatal norepinephrine levels, higher post-delivery epinephrine levels, and lower cortisol levels at every data collection period. Norepinephrine and cortisol, but not epinephrine, showed moderate correlations between pregnancy and labor, and moderate to high intercorrelations in labor, suggesting consistency in subject status for the repeated measures. All cord arterial measures are lower and uncorrelated to the Phase 4 maternal samples. After analgesia and epidural anesthesia, maternal levels of epinephrine in Phase 3 are significantly decreased. The results show that catecholamines and cortisol vary with parity, phase of labor, analgesia and epidural anesthesia.

Original languageEnglish (US)
Pages (from-to)57-69
Number of pages13
JournalJournal of Psychosomatic Obstetrics and Gynecology
Volume10
Issue number1
DOIs
StatePublished - 1989

Fingerprint

Umbilical Arteries
Umbilical Cord
Epinephrine
Hydrocortisone
Norepinephrine
Pregnancy
Epidural Anesthesia
Mothers
Analgesia
First Labor Stage
Third Pregnancy Trimester
Parity
Catecholamines

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Psychiatry and Mental health
  • Reproductive Medicine
  • Clinical Psychology

Cite this

Plasma epinephrine, norepinephrine, and cortisol of multigravidas in pregnancy and labor and in umbilical cord arteries after delivery. / Lederman, R. P.; Lederman, E.; Work, B. A.; McCann, D. S.

In: Journal of Psychosomatic Obstetrics and Gynecology, Vol. 10, No. 1, 1989, p. 57-69.

Research output: Contribution to journalArticle

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