Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature

Giuseppe Chiossi, Joel A. Spero, Emmanuel J. Esaka, Kristin Novic, Jennifer U. Celebrezze, Steven H. Golde, Ronald L. Thomas

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalAmerican Journal of Perinatology
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Factor X deficiency
  • Plasma exchange
  • Pregnancy
  • Prothrombin complex concentrates

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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    Chiossi, G., Spero, J. A., Esaka, E. J., Novic, K., Celebrezze, J. U., Golde, S. H., & Thomas, R. L. (2008). Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature. American Journal of Perinatology, 25(3), 189-192. https://doi.org/10.1055/s-2008-1061499