Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature

Giuseppe Chiossi; Joel A. Spero; Emmanuel J. Esaka; Kristin Novic; Jennifer U. Celebrezze; Steven H. Golde; Ronald L. Thomas

doi:10.1055/s-2008-1061499

Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature

Giuseppe Chiossi, Joel A. Spero, Emmanuel J. Esaka, Kristin Novic, Jennifer U. Celebrezze, Steven H. Golde, Ronald L. Thomas

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.

Original language	English (US)
Pages (from-to)	189-192
Number of pages	4
Journal	American Journal of Perinatology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1055/s-2008-1061499
State	Published - Mar 2008
Externally published	Yes

Keywords

Factor X deficiency
Plasma exchange
Pregnancy
Prothrombin complex concentrates

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1055/s-2008-1061499

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abstract = "Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.",

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AU - Esaka, Emmanuel J.

AU - Novic, Kristin

AU - Celebrezze, Jennifer U.

AU - Golde, Steven H.

AU - Thomas, Ronald L.

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AB - Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.

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KW - Pregnancy

KW - Prothrombin complex concentrates

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Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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