Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature

Giuseppe Chiossi, Joel A. Spero, Emmanuel J. Esaka, Kristin Novic, Jennifer U. Celebrezze, Steven H. Golde, Ronald L. Thomas

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalAmerican Journal of Perinatology
Volume25
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Factor X Deficiency
Plasma Exchange
Pregnancy
Factor X
Postpartum Period
Hemorrhage
Costs and Cost Analysis

Keywords

  • Factor X deficiency
  • Plasma exchange
  • Pregnancy
  • Prothrombin complex concentrates

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Chiossi, G., Spero, J. A., Esaka, E. J., Novic, K., Celebrezze, J. U., Golde, S. H., & Thomas, R. L. (2008). Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature. American Journal of Perinatology, 25(3), 189-192. https://doi.org/10.1055/s-2008-1061499

Plasma exchange in a case of severe factor X deficiency in pregnancy : Critical review of the literature. / Chiossi, Giuseppe; Spero, Joel A.; Esaka, Emmanuel J.; Novic, Kristin; Celebrezze, Jennifer U.; Golde, Steven H.; Thomas, Ronald L.

In: American Journal of Perinatology, Vol. 25, No. 3, 03.2008, p. 189-192.

Research output: Contribution to journalArticle

Chiossi, G, Spero, JA, Esaka, EJ, Novic, K, Celebrezze, JU, Golde, SH & Thomas, RL 2008, 'Plasma exchange in a case of severe factor X deficiency in pregnancy: Critical review of the literature', American Journal of Perinatology, vol. 25, no. 3, pp. 189-192. https://doi.org/10.1055/s-2008-1061499
Chiossi, Giuseppe ; Spero, Joel A. ; Esaka, Emmanuel J. ; Novic, Kristin ; Celebrezze, Jennifer U. ; Golde, Steven H. ; Thomas, Ronald L. / Plasma exchange in a case of severe factor X deficiency in pregnancy : Critical review of the literature. In: American Journal of Perinatology. 2008 ; Vol. 25, No. 3. pp. 189-192.
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