Abstract
We tested the hypotheses that the levels of insulin-like growth factor I (IGF-I) reflect the degree of control during the treatment of patients with congenital adrenal hyperplasia (CAH), and that suppressed IGF-I levels during puberty contribute to decreased adult height. We measured serial IGF-I levels in 26 CAH patients followed over 6 months to 5 years. The control of CAH was variable, with several cases of overtreatment in infancy, and frequent undertreatment in childhood and adolescence. IGF-I levels were quite variable and inconsistent with the control of CAH. Our results suggest that IGF-I levels are not helpful in monitoring CAH patients; IGF-I does not seem to play a role in the growth failure during CAH therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23-26 |
| Number of pages | 4 |
| Journal | Hormone Research in Paediatrics |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1990 |
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Keywords
- Congenital adrenal hyperplasia
- Growth
- Insulin-like growth factor I
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Pediatrics, Perinatology, and Child Health
Cite this
Plasma insulin-like growth factor I levels during treatment of congenital adrenal hyperplasia. / Cavallo, Anita; Furlanetto, Richard W.; Meyer, Walter.
In: Hormone Research in Paediatrics, Vol. 34, No. 1, 1990, p. 23-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma insulin-like growth factor I levels during treatment of congenital adrenal hyperplasia
AU - Cavallo, Anita
AU - Furlanetto, Richard W.
AU - Meyer, Walter
PY - 1990
Y1 - 1990
N2 - We tested the hypotheses that the levels of insulin-like growth factor I (IGF-I) reflect the degree of control during the treatment of patients with congenital adrenal hyperplasia (CAH), and that suppressed IGF-I levels during puberty contribute to decreased adult height. We measured serial IGF-I levels in 26 CAH patients followed over 6 months to 5 years. The control of CAH was variable, with several cases of overtreatment in infancy, and frequent undertreatment in childhood and adolescence. IGF-I levels were quite variable and inconsistent with the control of CAH. Our results suggest that IGF-I levels are not helpful in monitoring CAH patients; IGF-I does not seem to play a role in the growth failure during CAH therapy.
AB - We tested the hypotheses that the levels of insulin-like growth factor I (IGF-I) reflect the degree of control during the treatment of patients with congenital adrenal hyperplasia (CAH), and that suppressed IGF-I levels during puberty contribute to decreased adult height. We measured serial IGF-I levels in 26 CAH patients followed over 6 months to 5 years. The control of CAH was variable, with several cases of overtreatment in infancy, and frequent undertreatment in childhood and adolescence. IGF-I levels were quite variable and inconsistent with the control of CAH. Our results suggest that IGF-I levels are not helpful in monitoring CAH patients; IGF-I does not seem to play a role in the growth failure during CAH therapy.
KW - Congenital adrenal hyperplasia
KW - Growth
KW - Insulin-like growth factor I
UR - http://www.scopus.com/inward/record.url?scp=0025630049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025630049&partnerID=8YFLogxK
U2 - 10.1159/000181790
DO - 10.1159/000181790
M3 - Article
VL - 34
SP - 23
EP - 26
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
SN - 1663-2818
IS - 1
ER -