Plasma lipoproteins in cortical versus lacunar infarction

Robert J. Adams, Richard M. Carroll, Fenwick T. Nichols, Nancy McNair, Daniel S. Feldman, Elaine B. Feldman, William O. Thompson

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


We investigated the relation of plasma lipids to the risk for ischemic stroke by comparing clinical and biochemical characteristics of survivors of cortical (n=48) and lacunar (n=36) brain infarction. By analysis of variance, no differences were observed in the concentrations of total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, or apoproteins At and B. Patients with lacunar infarction, however, had higher concentrations of high density lipoprotein (HDL)-cholesterol than patients with cortical stroke. This HDI.-cholesterol difference was due primarily to a strikingly low HDL-cholesterol content in white patients with cortical stroke. These data suggest that previously demonstrated differences in HDL-cholesterol concentrations between patients with ischemic stroke and control subjects without stroke may apply to patients with cortical but not lacunar infarction. Separation of cerebral infarction Into subtypes based on mechanism may help clarify lipid- related risk factors in cerebrovascular disease.

Original languageEnglish (US)
Pages (from-to)448-452
Number of pages5
Issue number4
StatePublished - Apr 1989
Externally publishedYes


  • Cerebral infarction
  • Cholesterol
  • Lacunar infarction
  • Lipids

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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