Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection

H. M C Shantha Kumara, Samer T. Tohme, Sonali A C Herath, Xiaohong Yan, Anthony J. Senagore, Abu Nasar, Matthew F. Kalady, Raymond Baxter, Richard L. Whelan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study's purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients. Methods Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3 and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student's t test was used for data analysis (significance, P <0.008 after Bonferroni correction). Results The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3%. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM- 1 level was significantly higher on POD 1 (905.7 ± 292.4, P <0.001) and POD 3 (977.7 ± 271.8, P <0.001). Levels remained significantly elevated for the POD 7-13, POD 14-20, POD 21-27, and POD 28-67 time blocks. Conclusions MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.

Original languageEnglish (US)
Pages (from-to)1759-1764
Number of pages6
JournalSurgical Endoscopy and Other Interventional Techniques
Volume26
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Vascular Cell Adhesion Molecule-1
Blood Vessels
Colorectal Neoplasms
Endothelial Cells
Angiopoietin-2
Residual Neoplasm
Chemotaxis
Vascular Endothelial Growth Factor A
Cell Movement
Colon
Enzyme-Linked Immunosorbent Assay
Cell Proliferation
Students
Wounds and Injuries
Growth
Neoplasms
Proteins

Keywords

  • Colon cancer
  • Colorectal resection
  • Soluble vascular adhesion molecule
  • Surgery-related plasma alterations

ASJC Scopus subject areas

  • Surgery

Cite this

Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection. / Kumara, H. M C Shantha; Tohme, Samer T.; Herath, Sonali A C; Yan, Xiaohong; Senagore, Anthony J.; Nasar, Abu; Kalady, Matthew F.; Baxter, Raymond; Whelan, Richard L.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 26, No. 6, 06.2012, p. 1759-1764.

Research output: Contribution to journalArticle

Kumara, H. M C Shantha ; Tohme, Samer T. ; Herath, Sonali A C ; Yan, Xiaohong ; Senagore, Anthony J. ; Nasar, Abu ; Kalady, Matthew F. ; Baxter, Raymond ; Whelan, Richard L. / Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection. In: Surgical Endoscopy and Other Interventional Techniques. 2012 ; Vol. 26, No. 6. pp. 1759-1764.
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abstract = "Introduction Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study's purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients. Methods Blood samples from 90 patients (26{\%} rectal, 74{\%} colon) were obtained preoperatively, on postoperative days (POD) 1 and 3 and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student's t test was used for data analysis (significance, P <0.008 after Bonferroni correction). Results The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3{\%}. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM- 1 level was significantly higher on POD 1 (905.7 ± 292.4, P <0.001) and POD 3 (977.7 ± 271.8, P <0.001). Levels remained significantly elevated for the POD 7-13, POD 14-20, POD 21-27, and POD 28-67 time blocks. Conclusions MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.",
keywords = "Colon cancer, Colorectal resection, Soluble vascular adhesion molecule, Surgery-related plasma alterations",
author = "Kumara, {H. M C Shantha} and Tohme, {Samer T.} and Herath, {Sonali A C} and Xiaohong Yan and Senagore, {Anthony J.} and Abu Nasar and Kalady, {Matthew F.} and Raymond Baxter and Whelan, {Richard L.}",
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T1 - Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection

AU - Kumara, H. M C Shantha

AU - Tohme, Samer T.

AU - Herath, Sonali A C

AU - Yan, Xiaohong

AU - Senagore, Anthony J.

AU - Nasar, Abu

AU - Kalady, Matthew F.

AU - Baxter, Raymond

AU - Whelan, Richard L.

PY - 2012/6

Y1 - 2012/6

N2 - Introduction Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study's purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients. Methods Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3 and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student's t test was used for data analysis (significance, P <0.008 after Bonferroni correction). Results The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3%. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM- 1 level was significantly higher on POD 1 (905.7 ± 292.4, P <0.001) and POD 3 (977.7 ± 271.8, P <0.001). Levels remained significantly elevated for the POD 7-13, POD 14-20, POD 21-27, and POD 28-67 time blocks. Conclusions MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.

AB - Introduction Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study's purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients. Methods Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3 and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student's t test was used for data analysis (significance, P <0.008 after Bonferroni correction). Results The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3%. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM- 1 level was significantly higher on POD 1 (905.7 ± 292.4, P <0.001) and POD 3 (977.7 ± 271.8, P <0.001). Levels remained significantly elevated for the POD 7-13, POD 14-20, POD 21-27, and POD 28-67 time blocks. Conclusions MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.

KW - Colon cancer

KW - Colorectal resection

KW - Soluble vascular adhesion molecule

KW - Surgery-related plasma alterations

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U2 - 10.1007/s00464-011-2112-4

DO - 10.1007/s00464-011-2112-4

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