Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection

H. M.C.Shantha Kumara, Samer T. Tohme, Sonali A.C. Herath, Xiaohong Yan, Anthony J. Senagore, Abu Nasar, Matthew F. Kalady, Raymond Baxter, Richard L. Whelan

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    12 Scopus citations

    Abstract

    Introduction Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which are critical to wound and tumor angiogenesis. Soluble vascular cell adhesion molecule-1 (sVCAM-1) stimulates EC chemotaxis and angiogenesis. The impact of MICR on blood levels of sVCAM-1 is unknown. This study's purpose was to determine plasma sVCAM-1 levels after MICR in colorectal cancer (CRC) patients. Methods Blood samples from 90 patients (26% rectal, 74% colon) were obtained preoperatively, on postoperative days (POD) 1 and 3 and at other points during the next 2 months. The late samples were bundled into 7-day time blocks. sVCAM-1 levels were determined in duplicate via ELISA and reported as ng/ml. Student's t test was used for data analysis (significance, P < 0.008 after Bonferroni correction). Results The mean incision length was 7.3 ± 3.1 cm, and the conversion rate was 3%. Compared with preoperative (PreOp) levels (811.3 ± 233.2), the mean plasma sVCAM- 1 level was significantly higher on POD 1 (905.7 ± 292.4, P < 0.001) and POD 3 (977.7 ± 271.8, P < 0.001). Levels remained significantly elevated for the POD 7-13, POD 14-20, POD 21-27, and POD 28-67 time blocks. Conclusions MICR for CRC is associated with a persistent increase in plasma sVCAM-1 levels during the first month. This sustained increase may promote angiogenesis and stimulate the growth of residual tumor cells early after surgery.

    Original languageEnglish (US)
    Pages (from-to)1759-1764
    Number of pages6
    JournalSurgical Endoscopy
    Volume26
    Issue number6
    DOIs
    StatePublished - Jun 2012

    Keywords

    • Colon cancer
    • Colorectal resection
    • Soluble vascular adhesion molecule
    • Surgery-related plasma alterations

    ASJC Scopus subject areas

    • Surgery

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    Kumara, H. M. C. S., Tohme, S. T., Herath, S. A. C., Yan, X., Senagore, A. J., Nasar, A., Kalady, M. F., Baxter, R., & Whelan, R. L. (2012). Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection. Surgical Endoscopy, 26(6), 1759-1764. https://doi.org/10.1007/s00464-011-2112-4