Plasma substance p levels in normotensive and hypertensive subjects

W. B. Campbell, O. B. Holland, C. E. Gomez-Sanchez, R. M. Graham, W. A. Pettinger, A. C. White

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Since substance P is a potent natriuretic, diuretic, and vaso-dilatory peptide, a radioimmunoassay for substance P was developed, and its levels measured in the plasma of normal subjects and patients with essential hypertension. The plasma substance P levels were 186±14 pg/ml in normal subjects and 164±3 pg/ml in hypertensive patients. When the sodium content of their diet was reduced to 10 mEq/day, substance P levels failed to change, but plasma renin activity and urinary kallikrein increased. An acute saline infusion also failed to alter plasma substance P levels. Assuming an upright posture increased plasma renin activity, but not substance P, in both groups of subjects. Thus, it appears that substance P is not involved in the control of blood pressure, kallikrein excretion or renin release in man.

Original languageEnglish (US)
Pages (from-to)183-193
Number of pages11
JournalClinical and Experimental Hypertension
Volume3
Issue number2
DOIs
StatePublished - 1981

Fingerprint

Substance P
Renin
Tissue Kallikreins
Kallikreins
Posture
Diuretics
Radioimmunoassay
Sodium
Diet
Blood Pressure
Peptides

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Campbell, W. B., Holland, O. B., Gomez-Sanchez, C. E., Graham, R. M., Pettinger, W. A., & White, A. C. (1981). Plasma substance p levels in normotensive and hypertensive subjects. Clinical and Experimental Hypertension, 3(2), 183-193. https://doi.org/10.3109/10641968109033659

Plasma substance p levels in normotensive and hypertensive subjects. / Campbell, W. B.; Holland, O. B.; Gomez-Sanchez, C. E.; Graham, R. M.; Pettinger, W. A.; White, A. C.

In: Clinical and Experimental Hypertension, Vol. 3, No. 2, 1981, p. 183-193.

Research output: Contribution to journalArticle

Campbell, WB, Holland, OB, Gomez-Sanchez, CE, Graham, RM, Pettinger, WA & White, AC 1981, 'Plasma substance p levels in normotensive and hypertensive subjects', Clinical and Experimental Hypertension, vol. 3, no. 2, pp. 183-193. https://doi.org/10.3109/10641968109033659
Campbell WB, Holland OB, Gomez-Sanchez CE, Graham RM, Pettinger WA, White AC. Plasma substance p levels in normotensive and hypertensive subjects. Clinical and Experimental Hypertension. 1981;3(2):183-193. https://doi.org/10.3109/10641968109033659
Campbell, W. B. ; Holland, O. B. ; Gomez-Sanchez, C. E. ; Graham, R. M. ; Pettinger, W. A. ; White, A. C. / Plasma substance p levels in normotensive and hypertensive subjects. In: Clinical and Experimental Hypertension. 1981 ; Vol. 3, No. 2. pp. 183-193.
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