Plasma substance p levels in normotensive and hypertensive subjects

W. B. Campbell, O. B. Holland, C. E. Gomez-Sanchez, R. M. Graham, W. A. Pettinger, A. C. White

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Since substance P is a potent natriuretic, diuretic, and vaso-dilatory peptide, a radioimmunoassay for substance P was developed, and its levels measured in the plasma of normal subjects and patients with essential hypertension. The plasma substance P levels were 186±14 pg/ml in normal subjects and 164±3 pg/ml in hypertensive patients. When the sodium content of their diet was reduced to 10 mEq/day, substance P levels failed to change, but plasma renin activity and urinary kallikrein increased. An acute saline infusion also failed to alter plasma substance P levels. Assuming an upright posture increased plasma renin activity, but not substance P, in both groups of subjects. Thus, it appears that substance P is not involved in the control of blood pressure, kallikrein excretion or renin release in man.

Original languageEnglish (US)
Pages (from-to)183-193
Number of pages11
JournalClinical and Experimental Hypertension
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology


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