TY - JOUR
T1 - Plasma substance p levels in normotensive and hypertensive subjects
AU - Campbell, W. B.
AU - Holland, O. B.
AU - Gomez-Sanchez, C. E.
AU - Graham, R. M.
AU - Pettinger, W. A.
AU - White, A. C.
N1 - Funding Information:
ACKNOWLEDGMENT The authors express their appreciation to Stephanie Wooten for her secretarial assistance. These studies were supported by PHS grant 5-SOlRR05426-14 and M01-RR-00633, by grants from the National Institutes of Health (HL 21066 and HL 18730) and by a grant-in-aid from the American Heart Association and i t s Texas Affiliate. Drs. Gomez-Sanchez and Campbell are recipients o f a Research Career Development Awards from the National Institutes of Health (K04-HL00801 and K04-HL00429, respectively).
PY - 1981
Y1 - 1981
N2 - Since substance P is a potent natriuretic, diuretic, and vaso-dilatory peptide, a radioimmunoassay for substance P was developed, and its levels measured in the plasma of normal subjects and patients with essential hypertension. The plasma substance P levels were 186±14 pg/ml in normal subjects and 164±3 pg/ml in hypertensive patients. When the sodium content of their diet was reduced to 10 mEq/day, substance P levels failed to change, but plasma renin activity and urinary kallikrein increased. An acute saline infusion also failed to alter plasma substance P levels. Assuming an upright posture increased plasma renin activity, but not substance P, in both groups of subjects. Thus, it appears that substance P is not involved in the control of blood pressure, kallikrein excretion or renin release in man.
AB - Since substance P is a potent natriuretic, diuretic, and vaso-dilatory peptide, a radioimmunoassay for substance P was developed, and its levels measured in the plasma of normal subjects and patients with essential hypertension. The plasma substance P levels were 186±14 pg/ml in normal subjects and 164±3 pg/ml in hypertensive patients. When the sodium content of their diet was reduced to 10 mEq/day, substance P levels failed to change, but plasma renin activity and urinary kallikrein increased. An acute saline infusion also failed to alter plasma substance P levels. Assuming an upright posture increased plasma renin activity, but not substance P, in both groups of subjects. Thus, it appears that substance P is not involved in the control of blood pressure, kallikrein excretion or renin release in man.
UR - https://www.scopus.com/pages/publications/0019831528
UR - https://www.scopus.com/pages/publications/0019831528#tab=citedBy
U2 - 10.3109/10641968109033659
DO - 10.3109/10641968109033659
M3 - Article
C2 - 6163596
AN - SCOPUS:0019831528
SN - 1064-1963
VL - 3
SP - 183
EP - 193
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 2
ER -