Las células dendríticas plasmacitoides evocan la respuesta efectora de CTL Salmonella-específicos

Translated title of the contribution: Plasmacytoid dendritic cells evoke the Salmonella-specific CTL effector response

Carolina del Carmen Murúa-López, Maria Gonzalez Orozco, Héctor Samuel López-Moreno

Research output: Contribution to journalArticle

Abstract

Introduction: The immunological role of Plasmacytoid Dendritic Cells (pDC) in bacterial infections such as Salmonella, is poorly known. Therefore, we analysed the effector function of pDC to present S. Typhimurium antigens to cytotoxic T lymphocytes (CTL). Objective: To analyze the cytotoxic T Lymphocytes Salmonella-specific response evoked by Plasmacytoid Dendritic Cells (pDC). Material and methods: pDC CFSE-stained and pulsed withOmpC73 Salmonella Kb-restricted epitopes or S. Typhimurium infected, were used as target in cytotoxicity assays. Results: Specific lysis was statically significant in pDC+OmpC73 for all E:T ratios (p ≤ 0.05); for pDC+S. Typhimurium statistical significance was only observed at 1:100 ratio (p ≤ 0.05) using OmpC73. Conclusion: pDC can evoke cytotoxic T lymphocytes responses during S. Typhimurium infection.

Translated title of the contributionPlasmacytoid dendritic cells evoke the Salmonella-specific CTL effector response
Original languageSpanish
Pages (from-to)1-23
Number of pages23
JournalBiomedica
Volume39
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Cytotoxic
  • Cytotoxicity
  • Dendritic cells
  • Epitopes
  • Immunologic
  • Salmonella
  • T-lymphocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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