Plasmapheresis for diffuse alveolar hemorrhage in a patient with Wegener's granulomatosis: Case report and review of the literature

Thong Nguyen, Meri King Martin, Alexander J. Indrikovs

Research output: Contribution to journalArticle

21 Scopus citations


We present a case of a 20-year-old male with Wegener's Granulomatosis involving the upper respiratory tract, lungs, and kidneys. In his fourth hospital admission, the patient presented with diffuse alveolar hemorrhage and poor pulmonary function: FiO2 of 100% and PEEP of 17cm H2O on intubation. Due to a fast clinical deterioration while receiving drug therapy (cyclophosphamide and methylprednisolone), we performed nine daily 1-volume therapeutic plasma exchanges (TPE) using 5% albumin as replacement fluid. TPE resulted in a decrease in cytoplasmic anti-neutrophil cytoplasm antibodies (c-ANCA) titer from 1:1,024 to 1:16. On the ninth day of plasmapheresis, his pulmonary status was markedly improved with FiO2 of 60% and PEEP of 8 cm H2O. The patient was later extubated and discharged home in stable condition. Wegener's Granulomatosis with pulmonary hemorrhage is not included in the current guidelines for therapeutic apheresis; therefore, we report this case and, if warranted, propose this condition to be included in the guidelines.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalJournal of Clinical Apheresis
Issue number4
StatePublished - Dec 1 2005



  • Diffuse alveolar hemorrhage
  • Glomerulonephritis
  • Therapeutic plasma exchange
  • Wegener's granulomatosis
  • c-ANCA

ASJC Scopus subject areas

  • Hematology

Cite this