Plausible mechanism of inactivation of plasma α1-proteinase inhibitor by acrolein

J. C. Gan, G. A.S. Ansari

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Evidence is presented to show that inactivation of α1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number3
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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