Plausible mechanism of inactivation of plasma α1-proteinase inhibitor by acrolein

J. C. Gan, G. A.S. Ansari

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Evidence is presented to show that inactivation of α1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume55
Issue number3
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology

Fingerprint

Dive into the research topics of 'Plausible mechanism of inactivation of plasma α1-proteinase inhibitor by acrolein'. Together they form a unique fingerprint.

Cite this