Plausible mechanism of inactivation of plasma α1-proteinase inhibitor by acrolein

J. C. Gan, Ghulam Ansari

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Evidence is presented to show that inactivation of α1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume55
Issue number3
StatePublished - 1987

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Acrolein
Histidine
Lysine
Peptide Hydrolases
Plasmas

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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title = "Plausible mechanism of inactivation of plasma α1-proteinase inhibitor by acrolein",
abstract = "Evidence is presented to show that inactivation of α1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90{\%} activity was lost when twenty three lysine and eight histidine residues were modified.",
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