Plausible mechanism of inactivation of plasma α1-proteinase inhibitor by acrolein

J. C. Gan; G. A.S. Ansari

Plausible mechanism of inactivation of plasma α₁-proteinase inhibitor by acrolein

J. C. Gan
, G. A.S. Ansari

Research output: Contribution to journal › Article › peer-review

Abstract

Evidence is presented to show that inactivation of α₁-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.

Original language	English (US)
Pages (from-to)	419-422
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	55
Issue number	3
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pathology and Forensic Medicine
Toxicology
Pharmacology

Cite this

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title = "Plausible mechanism of inactivation of plasma α1-proteinase inhibitor by acrolein",

abstract = "Evidence is presented to show that inactivation of α1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90\% activity was lost when twenty three lysine and eight histidine residues were modified.",

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year = "1987",

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AN - SCOPUS:0023091093

SN - 0034-5164

VL - 55

SP - 419

EP - 422

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 3

ER -

Plausible mechanism of inactivation of plasma α₁-proteinase inhibitor by acrolein

Abstract

ASJC Scopus subject areas

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