Pneumonitis in Syrian golden hamsters (Mesocricetus auratus) infected with Rio Mamoré virus (family Bunyaviridae, genus Hantavirus)

Mary Louise Milazzo, Eduardo J. Eyzaguirre, Charles F. Fulhorst

Research output: Contribution to journalArticle

Abstract

Rio Mamoré virus is an etiological agent of hantavirus pulmonary syndrome in South America. The purpose of this study was to determine whether Rio Mamoré virus strain HTN-007 in Syrian golden hamsters is pathogenic. None of 37 adult hamsters infected by intramuscular injection of HTN-007, including 10 animals killed on Day 42 or 43 post-inoculation, exhibited any symptom of disease. Histological abnormalities included severe or moderately severe pneumonitis in 6 (46.2%) of the 13 animals killed on Day 7 or 10 post-inoculation. The primary target of infection in lung was the endothelium of the microvasculature. Collectively, these results indicate that Rio Mamoré virus strain HTN-007 in adult Syrian golden hamsters can cause a nonlethal disease that is pathologically similar to hantavirus pulmonary syndrome.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalVirus Research
Volume191
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Hantavirus pulmonary syndrome
  • Maporal virus
  • Rio Mamoré virus

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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