Pneumonitis in Syrian golden hamsters (Mesocricetus auratus) infected with Rio Mamoré virus (family Bunyaviridae, genus Hantavirus)

Mary Louise Milazzo, Eduardo J. Eyzaguirre, Charles F. Fulhorst

Research output: Contribution to journalArticlepeer-review

Abstract

Rio Mamoré virus is an etiological agent of hantavirus pulmonary syndrome in South America. The purpose of this study was to determine whether Rio Mamoré virus strain HTN-007 in Syrian golden hamsters is pathogenic. None of 37 adult hamsters infected by intramuscular injection of HTN-007, including 10 animals killed on Day 42 or 43 post-inoculation, exhibited any symptom of disease. Histological abnormalities included severe or moderately severe pneumonitis in 6 (46.2%) of the 13 animals killed on Day 7 or 10 post-inoculation. The primary target of infection in lung was the endothelium of the microvasculature. Collectively, these results indicate that Rio Mamoré virus strain HTN-007 in adult Syrian golden hamsters can cause a nonlethal disease that is pathologically similar to hantavirus pulmonary syndrome.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalVirus Research
Volume191
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Hantavirus pulmonary syndrome
  • Maporal virus
  • Rio Mamoré virus

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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