Podocyte biology and pathogenesis of kidney disease

Jochen Reiser, Sanja Sever

Research output: Contribution to journalArticlepeer-review

151 Scopus citations


Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly caused by genetic mutations, has become a global pandemic that severely diminishes the quality of life for millions. Despite the changing face of CKD, treatment options and resources remain woefully antiquated and have failed to arrest or reverse the effects of kidney-related diseases. Histological and genetic data strongly implicate one promising target: the podocyte. Podocytes are terminally differentiated cells of the kidney glomerulus that are essential for the integrity of the kidney filter. Their function is primarily based on their intricate structure, which includes foot processes. Loss of these actindriven membrane extensions is tightly connected to the presence of protein in the urine, podocyte loss, development of CKD, and ultimately renal failure.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalAnnual review of medicine
StatePublished - Jan 14 2013
Externally publishedYes


  • CKD
  • actin cytoskeleton
  • dynamin
  • novel therapeutics
  • suPAR

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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