Abstract
Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as feasible therapeutics for treating chronic kidney diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 381-384 |
| Number of pages | 4 |
| Journal | Periodicum Biologorum |
| Volume | 118 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2016 |
| Externally published | Yes |
Keywords
- Actin cytoskeleton
- Chronic kidney disease
- Podocyte
- Proteinuria
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences