Podocytes and the actin cytoskeleton as a feasible therapeutic target

Sanja Sever, Changkyu Gu

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as feasible therapeutics for treating chronic kidney diseases.

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalPeriodicum Biologorum
Issue number4
StatePublished - 2016
Externally publishedYes


  • Actin cytoskeleton
  • Chronic kidney disease
  • Podocyte
  • Proteinuria

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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