Polistes wasp hypersensitivity

Diagnosis by venom-induced release of histamine in vitro

Steven R. Findlay, J. E. Gillaspy, Ralph Lord, Larry S. Weiner, J. Andrew Grant

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Polistes wasps cause a majority of Hymenoptera-induced anaphylactic reactions in Texas. Using the in vitro release of histamine from basophils of patients allergic to Polistes stings, we have studied the cross-reactivity of venoms from three species of Polistes wasps as well as the cross-reactivity among Polistes, honeybee, and Vespula maculifrons (yellow jacket) venoms. Venom collected by an extrusion technique from Pollistes exclamans, Pollistes apachus, and Pollistes Carolina caused release of histamine in seven Polistes-sensitive individuals. The dose-response curves from all three Polistes species were quite similar, suggesting extensive cross-reactivity among these species. None of these patients showed significant release of histamine from leukocytes exposed to yellow jacket or honeybee venom. We conclude that a source of Polistes venom is available for further study and possibly for therapy. It appears that any of three local common species of Polistes wasps could be used. Our studies confirmed earlier reports that Hymenoptera sensitivity is often genus-specific.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume60
Issue number4
DOIs
StatePublished - 1977

Fingerprint

Wasps
Histamine Release
Venoms
Hypersensitivity
Hymenoptera
Basophils
Anaphylaxis
Bites and Stings
Leukocytes
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Polistes wasp hypersensitivity : Diagnosis by venom-induced release of histamine in vitro. / Findlay, Steven R.; Gillaspy, J. E.; Lord, Ralph; Weiner, Larry S.; Grant, J. Andrew.

In: The Journal of Allergy and Clinical Immunology, Vol. 60, No. 4, 1977, p. 230-235.

Research output: Contribution to journalArticle

Findlay, Steven R. ; Gillaspy, J. E. ; Lord, Ralph ; Weiner, Larry S. ; Grant, J. Andrew. / Polistes wasp hypersensitivity : Diagnosis by venom-induced release of histamine in vitro. In: The Journal of Allergy and Clinical Immunology. 1977 ; Vol. 60, No. 4. pp. 230-235.
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