Poly-ADP-ribose polymerase inhibition reduces mesenteric injury after cardiopulmonary bypass

Gábor Szabó, L. Seres, P. Soós, C. Flechtenmacher, Z. Zsengellér, F. U. Sack, C. Szabó, S. Hagl

    Research output: Contribution to journalArticle

    3 Scopus citations

    Abstract

    Background: We investigated the effects of PARS inhibition on intestinal injury in a canine model of cardiopulmonary bypass (CPB). Methods: Twelve dogs underwent 90 minutes of hypothermic CPB. 6 dogs received 5 mg/kg PJ34, a selective PARP inhibitor during CPB, 6 vehicle-treated animals served as controls. Mesenteric blood flow (MBF) and mesenteric vascular resistance (MVR) were measured before and 60 minutes after weaning from CPB. Endothelium- dependent vasorelaxation to acetylcholine (ACH) and endothelium-independent vasorelaxation to sodium-nitroprussid (SNP) were expressed as percent change of MVR. In addition, mesenteric creatinkinase (CK) and lactate release were determined. Results: Baseline hemodynamics, MBF, response to ACH (- 41 ± 3 vs. - 55 ± 6%) and SNP (- 60 ± 2 vs. - 56 ± 4%) did not differ significantly between the groups. The response to ACH decreased significantly in the control group while it remained unchanged in the PJ34 group (- 29 ± 5 vs. - 46 ± 9%, p < 0.05). The response to SNP did not change. Mesenteric CK release (325 ± 99 vs. 16 ± 10 U/l, p < 0.05) and lactate production (0.96 ± 0.17 vs. 0.4 ± 0.2 mmol/l, p < 0.05) were significantly lower in the PJ34 group. Conclusion: PARP inhibition prevents CPB-induced mesenteric endothelial dysfunction and tissue damage.

    Original languageEnglish (US)
    Pages (from-to)338-343
    Number of pages6
    JournalThoracic and Cardiovascular Surgeon
    Volume52
    Issue number6
    DOIs
    StatePublished - Dec 1 2004

    Keywords

    • Cardiopulmonary bypass
    • Mesenteric injury
    • Poly (ADP-ribose) polymerase

    ASJC Scopus subject areas

    • Surgery
    • Pulmonary and Respiratory Medicine
    • Cardiology and Cardiovascular Medicine

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  • Cite this

    Szabó, G., Seres, L., Soós, P., Flechtenmacher, C., Zsengellér, Z., Sack, F. U., Szabó, C., & Hagl, S. (2004). Poly-ADP-ribose polymerase inhibition reduces mesenteric injury after cardiopulmonary bypass. Thoracic and Cardiovascular Surgeon, 52(6), 338-343. https://doi.org/10.1055/s-2004-821274