Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock

Csaba Szabo

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Various forms of circulatory shock are associated with a reduced responsiveness of arteries and veins to exogenous or endogenous vasoconstrictor agents (vascular hyporeactivity), myocardial dysfunction, and disrupted intracellular energetic processes, culminating in multiple organ failure and death. Some of these alterations previously have been suggested to be related to nitric oxide (NO) overproduction, due to the activation of the endothelial isoform of NO synthase (ecNOS) in the early stage and expression of a distinct inducible isoform of NOS (iNOS) in the late stage. 1-3.

Original languageEnglish (US)
Title of host publicationCell Death
Subtitle of host publicationThe Role of Poly (ADP-ribose) Polymerase
PublisherCRC Press
Pages81-102
Number of pages22
ISBN (Electronic)9781420038897
ISBN (Print)0849322677, 9780849322679
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Poly(ADP-ribose) Polymerases
Shock
Protein Isoforms
Chemical activation
Multiple Organ Failure
Nitric Oxide Synthase Type III
Vasoconstrictor Agents
Nitric Oxide Synthase
Blood Vessels
Veins
Nitric Oxide
Arteries

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Szabo, C. (2000). Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock. In Cell Death: The Role of Poly (ADP-ribose) Polymerase (pp. 81-102). CRC Press. https://doi.org/10.1201/9781420038897

Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock. / Szabo, Csaba.

Cell Death: The Role of Poly (ADP-ribose) Polymerase. CRC Press, 2000. p. 81-102.

Research output: Chapter in Book/Report/Conference proceedingChapter

Szabo, C 2000, Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock. in Cell Death: The Role of Poly (ADP-ribose) Polymerase. CRC Press, pp. 81-102. https://doi.org/10.1201/9781420038897
Szabo C. Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock. In Cell Death: The Role of Poly (ADP-ribose) Polymerase. CRC Press. 2000. p. 81-102 https://doi.org/10.1201/9781420038897
Szabo, Csaba. / Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock. Cell Death: The Role of Poly (ADP-ribose) Polymerase. CRC Press, 2000. pp. 81-102
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