Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock

Csaba Szabó

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Scopus citations


    Various forms of circulatory shock are associated with a reduced responsiveness of arteries and veins to exogenous or endogenous vasoconstrictor agents (vascular hyporeactivity), myocardial dysfunction, and disrupted intracellular energetic processes, culminating in multiple organ failure and death. Some of these alterations previously have been suggested to be related to nitric oxide (NO) overproduction, due to the activation of the endothelial isoform of NO synthase (ecNOS) in the early stage and expression of a distinct inducible isoform of NOS (iNOS) in the late stage. 1-3.

    Original languageEnglish (US)
    Title of host publicationCell Death
    Subtitle of host publicationThe Role of Poly (ADP-ribose) Polymerase
    PublisherCRC Press
    Number of pages22
    ISBN (Electronic)9781420038897
    ISBN (Print)0849322677, 9780849322679
    StatePublished - Jan 1 2000

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)
    • Pharmacology, Toxicology and Pharmaceutics(all)


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