Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock

Csaba Szabó

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Various forms of circulatory shock are associated with a reduced responsiveness of arteries and veins to exogenous or endogenous vasoconstrictor agents (vascular hyporeactivity), myocardial dysfunction, and disrupted intracellular energetic processes, culminating in multiple organ failure and death. Some of these alterations previously have been suggested to be related to nitric oxide (NO) overproduction, due to the activation of the endothelial isoform of NO synthase (ecNOS) in the early stage and expression of a distinct inducible isoform of NOS (iNOS) in the late stage. 1-3.

Original languageEnglish (US)
Title of host publicationCell Death
Subtitle of host publicationThe Role of Poly (ADP-ribose) Polymerase
PublisherCRC Press
Number of pages22
ISBN (Electronic)9781420038897
ISBN (Print)0849322677, 9780849322679
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


Dive into the research topics of 'Poly(ADP-ribose) polymerase activation and the pathogenesis of circulatory shock'. Together they form a unique fingerprint.

Cite this