Poly(ADP-ribose) polymerase activation in the reperfused myocardium

Gábor Szabó, Lucas Liaudet, Siegfried Hagl, Csaba Szabó

    Research output: Contribution to journalReview article

    65 Scopus citations

    Abstract

    The activation of poly(ADP-ribose) polymerase (PARP) is now considered a final common effector in various types of tissue injury including systemic inflammation, circulatory shock and ischemia/reperfusion. Free radical and oxidant production and related cytotoxicity during ischemia/reperfusion leads to DNA strand breakage which activates the nuclear enzyme PARP and initiates an energy-consuming, inefficient cellular metabolic cycle with transfer of the ADP-ribosyl moiety of NAD+ to protein acceptors. During the last 5 years, a growing number of experimental studies demonstrated the beneficial effects of PARP inhibition in cell cultures through rodent models and more recently in pre-clinical large animal models of regional and global ischemia/reperfusion injury. The objective of the current review is to provide an overview of the experimental evidence implicating PARP as a pathophysiological modulator of myocardial injury in vitro and in vivo.

    Original languageEnglish (US)
    Pages (from-to)471-480
    Number of pages10
    JournalCardiovascular research
    Volume61
    Issue number3
    DOIs
    StatePublished - Feb 15 2004

    Keywords

    • Heart
    • Oxidative stress
    • Peroxynitrite
    • Poly(ADP-ribose) polymerase
    • Reperfusion injury

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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