Poly(ADP-ribose) polymerase activation in the reperfused myocardium

Gábor Szabó, Lucas Liaudet, Siegfried Hagl, Csaba Szabo

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The activation of poly(ADP-ribose) polymerase (PARP) is now considered a final common effector in various types of tissue injury including systemic inflammation, circulatory shock and ischemia/reperfusion. Free radical and oxidant production and related cytotoxicity during ischemia/reperfusion leads to DNA strand breakage which activates the nuclear enzyme PARP and initiates an energy-consuming, inefficient cellular metabolic cycle with transfer of the ADP-ribosyl moiety of NAD+ to protein acceptors. During the last 5 years, a growing number of experimental studies demonstrated the beneficial effects of PARP inhibition in cell cultures through rodent models and more recently in pre-clinical large animal models of regional and global ischemia/reperfusion injury. The objective of the current review is to provide an overview of the experimental evidence implicating PARP as a pathophysiological modulator of myocardial injury in vitro and in vivo.

Original languageEnglish
Pages (from-to)471-480
Number of pages10
JournalCardiovascular Research
Volume61
Issue number3
DOIs
StatePublished - Feb 15 2004
Externally publishedYes

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Keywords

  • Heart
  • Oxidative stress
  • Peroxynitrite
  • Poly(ADP-ribose) polymerase
  • Reperfusion injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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