Polyamines in gastrointestinal cancer

Rami Saydjari, Courtney Townsend, Sam C. Barranco, James C. Thompson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Polyamines have important roles in determining the structure, function, and proliferative capacity of both normal and neoplastic gastrointestinal tissues. The numerous potential clinical uses of polyamines, their biosynthetic enzymes and enzyme inhibitors, as tumor markers and antitumor agents have been demonstrated in experimental and clinical settings. Gastrointestinal cancers account for a large percentage of cancer deaths in the United States. Colorectal cancer alone is the second most common cause of cancer death in the United States (85). With few exceptions, the studies summarized in this review are reports of observations. Our understanding of the underlying mechanisms causing these phenomena is fragmentary. The gastrointestinal system has unusual abilities to regenerate and an unusually high metabolic rate. The normal process of regeneration and adaptation may provide an excellent foundation upon which to build our understanding of malignant neoplastic processes in these tissues. Further investigation into the nature of the relationship between polyamines and gastrointestinal and hepatocellular neoplasia may provide tools that are useful in combating these diseases.

Original languageEnglish (US)
Pages (from-to)1629-1636
Number of pages8
JournalDigestive Diseases and Sciences
Volume34
Issue number10
DOIs
StatePublished - Oct 1989

Fingerprint

Gastrointestinal Neoplasms
Polyamines
Neoplastic Processes
Neoplasms
Enzyme Inhibitors
Tumor Biomarkers
Antineoplastic Agents
Regeneration
Cause of Death
Colorectal Neoplasms
Enzymes

Keywords

  • cancer
  • gastrointestinal
  • polyamines

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Saydjari, R., Townsend, C., Barranco, S. C., & Thompson, J. C. (1989). Polyamines in gastrointestinal cancer. Digestive Diseases and Sciences, 34(10), 1629-1636. https://doi.org/10.1007/BF01537125

Polyamines in gastrointestinal cancer. / Saydjari, Rami; Townsend, Courtney; Barranco, Sam C.; Thompson, James C.

In: Digestive Diseases and Sciences, Vol. 34, No. 10, 10.1989, p. 1629-1636.

Research output: Contribution to journalArticle

Saydjari, R, Townsend, C, Barranco, SC & Thompson, JC 1989, 'Polyamines in gastrointestinal cancer', Digestive Diseases and Sciences, vol. 34, no. 10, pp. 1629-1636. https://doi.org/10.1007/BF01537125
Saydjari, Rami ; Townsend, Courtney ; Barranco, Sam C. ; Thompson, James C. / Polyamines in gastrointestinal cancer. In: Digestive Diseases and Sciences. 1989 ; Vol. 34, No. 10. pp. 1629-1636.
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