Abstract
Polyamines have important roles in determining the structure, function, and proliferative capacity of both normal and neoplastic gastrointestinal tissues. The numerous potential clinical uses of polyamines, their biosynthetic enzymes and enzyme inhibitors, as tumor markers and antitumor agents have been demonstrated in experimental and clinical settings. Gastrointestinal cancers account for a large percentage of cancer deaths in the United States. Colorectal cancer alone is the second most common cause of cancer death in the United States (85). With few exceptions, the studies summarized in this review are reports of observations. Our understanding of the underlying mechanisms causing these phenomena is fragmentary. The gastrointestinal system has unusual abilities to regenerate and an unusually high metabolic rate. The normal process of regeneration and adaptation may provide an excellent foundation upon which to build our understanding of malignant neoplastic processes in these tissues. Further investigation into the nature of the relationship between polyamines and gastrointestinal and hepatocellular neoplasia may provide tools that are useful in combating these diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1629-1636 |
| Number of pages | 8 |
| Journal | Digestive Diseases and Sciences |
| Volume | 34 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1989 |
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Keywords
- cancer
- gastrointestinal
- polyamines
ASJC Scopus subject areas
- Gastroenterology
Cite this
Polyamines in gastrointestinal cancer. / Saydjari, Rami; Townsend, Courtney; Barranco, Sam C.; Thompson, James C.
In: Digestive Diseases and Sciences, Vol. 34, No. 10, 10.1989, p. 1629-1636.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polyamines in gastrointestinal cancer
AU - Saydjari, Rami
AU - Townsend, Courtney
AU - Barranco, Sam C.
AU - Thompson, James C.
PY - 1989/10
Y1 - 1989/10
N2 - Polyamines have important roles in determining the structure, function, and proliferative capacity of both normal and neoplastic gastrointestinal tissues. The numerous potential clinical uses of polyamines, their biosynthetic enzymes and enzyme inhibitors, as tumor markers and antitumor agents have been demonstrated in experimental and clinical settings. Gastrointestinal cancers account for a large percentage of cancer deaths in the United States. Colorectal cancer alone is the second most common cause of cancer death in the United States (85). With few exceptions, the studies summarized in this review are reports of observations. Our understanding of the underlying mechanisms causing these phenomena is fragmentary. The gastrointestinal system has unusual abilities to regenerate and an unusually high metabolic rate. The normal process of regeneration and adaptation may provide an excellent foundation upon which to build our understanding of malignant neoplastic processes in these tissues. Further investigation into the nature of the relationship between polyamines and gastrointestinal and hepatocellular neoplasia may provide tools that are useful in combating these diseases.
AB - Polyamines have important roles in determining the structure, function, and proliferative capacity of both normal and neoplastic gastrointestinal tissues. The numerous potential clinical uses of polyamines, their biosynthetic enzymes and enzyme inhibitors, as tumor markers and antitumor agents have been demonstrated in experimental and clinical settings. Gastrointestinal cancers account for a large percentage of cancer deaths in the United States. Colorectal cancer alone is the second most common cause of cancer death in the United States (85). With few exceptions, the studies summarized in this review are reports of observations. Our understanding of the underlying mechanisms causing these phenomena is fragmentary. The gastrointestinal system has unusual abilities to regenerate and an unusually high metabolic rate. The normal process of regeneration and adaptation may provide an excellent foundation upon which to build our understanding of malignant neoplastic processes in these tissues. Further investigation into the nature of the relationship between polyamines and gastrointestinal and hepatocellular neoplasia may provide tools that are useful in combating these diseases.
KW - cancer
KW - gastrointestinal
KW - polyamines
UR - http://www.scopus.com/inward/record.url?scp=0024412894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024412894&partnerID=8YFLogxK
U2 - 10.1007/BF01537125
DO - 10.1007/BF01537125
M3 - Article
C2 - 2676429
AN - SCOPUS:0024412894
VL - 34
SP - 1629
EP - 1636
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 10
ER -