Polyhydroxy-N-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential

Srinivasa Reddy Bonam; Jaggaiah Naidu Gorantla; Arun Kumar Thangarasu; Ravi Shankar Lankalapalli; Halmuthur Mahabalarao Sampath Kumar

doi:10.1080/07328303.2017.1413193

Polyhydroxy-N-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential

Srinivasa Reddy Bonam, Jaggaiah Naidu Gorantla, Arun Kumar Thangarasu, Ravi Shankar Lankalapalli, Halmuthur Mahabalarao Sampath Kumar

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A focused library of novel N-alkyl-2-pyrrolidinone derivatives 3a-e was synthesized from D-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.

Original language	English (US)
Pages (from-to)	30-43
Number of pages	14
Journal	Journal of Carbohydrate Chemistry
Volume	37
Issue number	1
DOIs	https://doi.org/10.1080/07328303.2017.1413193
State	Published - Jan 2 2018
Externally published	Yes

Keywords

cytokines
Dendritic cells
hPBMCs
macrophages
N-alkyl-2-pyrrolidinone

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1080/07328303.2017.1413193

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title = "Polyhydroxy-N-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential",

abstract = "A focused library of novel N-alkyl-2-pyrrolidinone derivatives 3a-e was synthesized from D-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.",

keywords = "cytokines, Dendritic cells, hPBMCs, macrophages, N-alkyl-2-pyrrolidinone",

author = "{Reddy Bonam}, Srinivasa and {Naidu Gorantla}, Jaggaiah and Thangarasu, {Arun Kumar} and Lankalapalli, {Ravi Shankar} and {Sampath Kumar}, {Halmuthur Mahabalarao}",

note = "Funding Information: Financial support from the Science and Engineering Research Board, Department of Science and Technology, Government of India, grant EMR/2015/000153, is gratefully acknowledged. This work was supported by DENOVA, 12th five year plan supra institutional project of CSIR-IICT (CSC0205). Publisher Copyright: {\textcopyright} 2018 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.",

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doi = "10.1080/07328303.2017.1413193",

language = "English (US)",

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AU - Reddy Bonam, Srinivasa

AU - Naidu Gorantla, Jaggaiah

AU - Thangarasu, Arun Kumar

AU - Lankalapalli, Ravi Shankar

AU - Sampath Kumar, Halmuthur Mahabalarao

N1 - Funding Information: Financial support from the Science and Engineering Research Board, Department of Science and Technology, Government of India, grant EMR/2015/000153, is gratefully acknowledged. This work was supported by DENOVA, 12th five year plan supra institutional project of CSIR-IICT (CSC0205). Publisher Copyright: © 2018 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.

PY - 2018/1/2

Y1 - 2018/1/2

N2 - A focused library of novel N-alkyl-2-pyrrolidinone derivatives 3a-e was synthesized from D-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.

AB - A focused library of novel N-alkyl-2-pyrrolidinone derivatives 3a-e was synthesized from D-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.

KW - cytokines

KW - Dendritic cells

KW - hPBMCs

KW - macrophages

KW - N-alkyl-2-pyrrolidinone

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Polyhydroxy-N-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential

Abstract

Keywords

ASJC Scopus subject areas

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