TY - JOUR
T1 - Polyhydroxy-N-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential
AU - Reddy Bonam, Srinivasa
AU - Naidu Gorantla, Jaggaiah
AU - Thangarasu, Arun Kumar
AU - Lankalapalli, Ravi Shankar
AU - Sampath Kumar, Halmuthur Mahabalarao
N1 - Funding Information:
Financial support from the Science and Engineering Research Board, Department of Science and Technology, Government of India, grant EMR/2015/000153, is gratefully acknowledged. This work was supported by DENOVA, 12th five year plan supra institutional project of CSIR-IICT (CSC0205).
Publisher Copyright:
© 2018 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - A focused library of novel N-alkyl-2-pyrrolidinone derivatives 3a-e was synthesized from D-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.
AB - A focused library of novel N-alkyl-2-pyrrolidinone derivatives 3a-e was synthesized from D-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.
KW - cytokines
KW - Dendritic cells
KW - hPBMCs
KW - macrophages
KW - N-alkyl-2-pyrrolidinone
UR - http://www.scopus.com/inward/record.url?scp=85041098390&partnerID=8YFLogxK
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U2 - 10.1080/07328303.2017.1413193
DO - 10.1080/07328303.2017.1413193
M3 - Article
AN - SCOPUS:85041098390
SN - 0732-8303
VL - 37
SP - 30
EP - 43
JO - Journal of Carbohydrate Chemistry
JF - Journal of Carbohydrate Chemistry
IS - 1
ER -