Polymorphism of MTHFR and MTRR in Czech patients with cardiovascular diseases and stroke

Reuben Matalon, S. Rady, K. Szucs, P. Matalon, J. Hyánek, P. Šebesta, J. Matoušková, N. Vondráčková, H. Pejznochová, L. Dubská, H. Přindisová, J. Dvořáková, M. Loučka, V. Martiniková, M. Šlancová

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3 Scopus citations

Abstract

Blood from 27 Czech patients with cardiovascular disease and stroke, who also had hyperhomocysteinemia, was analyzed for methylene tetrahydrofolate reductase (MTHFR) polymorphism. These patients had significantly higher incidence of MTHFR 677 C > T polymorphism compared to controls (p < 0.001). The incidence the MTHFR 1298 A > C and methionine synthase reductase (MTRR) 66 A > G polymorphism was not significantly different. The hyperhomocysteinemia in 70% of these patients was reversible by folate supplementation.

Original languageEnglish (US)
Pages (from-to)418-420
Number of pages3
JournalCesko-Slovenska Pediatrie
Volume58
Issue number7
StatePublished - 2003

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Matalon, R., Rady, S., Szucs, K., Matalon, P., Hyánek, J., Šebesta, P., Matoušková, J., Vondráčková, N., Pejznochová, H., Dubská, L., Přindisová, H., Dvořáková, J., Loučka, M., Martiniková, V., & Šlancová, M. (2003). Polymorphism of MTHFR and MTRR in Czech patients with cardiovascular diseases and stroke. Cesko-Slovenska Pediatrie, 58(7), 418-420.