Blood from 27 Czech patients with cardiovascular disease and stroke, who also had hyperhomocysteinemia, was analyzed for methylene tetrahydrofolate reductase (MTHFR) polymorphism. These patients had significantly higher incidence of MTHFR 677 C > T polymorphism compared to controls (p < 0.001). The incidence the MTHFR 1298 A > C and methionine synthase reductase (MTRR) 66 A > G polymorphism was not significantly different. The hyperhomocysteinemia in 70% of these patients was reversible by folate supplementation.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 2003|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health